快速MRI对胎儿胼胝体发育不全的诊断价值及与超声对照研究

Prenatal diagnosis of agenesis of the corpus callosum:fast MRI versus ultrasonography

目的:探讨快速MRI对胎儿胼胝体发育不全(ACC)的诊断价值,并与超声对比。方法:回顾性分析16例经引产证实ACC的胎儿,孕20-36周,平均30周,产前常规超声检查后1～3天内行胎儿颅脑快速MRI检查,采用单次激发快速自旋回波序列(SSTSE)和平衡式稳态自由进动序列(balance-FFE)行T2WI扫描,回顾性分析超声及产前MRI表现,并与引产后尸体MRI检查或尸体解剖结果对照。结果:16例ACC胎儿中,产前MRI明确诊断16例,诊断合并其他中枢系统畸形5例,与产后检查结果相符。超声明确诊断9例,可疑6例,误诊1例;合并畸形确诊4例,漏诊1例。结论:快速MRI对胎儿ACC的诊断优于超声,有助于明确诊断并判断其分型及合并畸形,可作为超声的补充诊断方法。

Objective：To compare accuracy of fast MRI and ultrasonography for detecting agenesis of the corpus callosum （ACC） in the fetus. Methods. A retrospective analysis of ultrasonography and fast MRI was performed in 16 fetuses with ACC proven by postmortem autopsy. Fast T2WI were performed utilizing single shot turbo spin echo （SSTSE） and balance fast field echo （balance-FFE）. Fast T2 WI sequences were performed in all fetuses. Prenatal ultrasound and MR ima- ging findings were compared to the finding documented in the autopsy. Results：All the 16 cases of ACC,together with 5 cases with other associated brain abnormalities, were shown more clearly on MRI. 9 cases of ACC were demonstrated and the diagnosis of ACC in 6 cases was suspected on ultrasonography, 1 case was misdiagnosed. Of 5 cases with other brain associated abnormalities,4 were demonstrated and one was misdiagnosed on ultrasonography. Conelusion：Fast MRI has advantages to ultrasonography in detecting ACC and other associated abnormalities and is supplement to ultrasonography in complicated pregnancies.