不同分子亚型乳腺癌超声及MRI特征

Ultrasonic and MRI features of breast cancers of different molecular subtypes

目的探讨不同分子亚型乳腺癌超声和MRI表现。方法回顾性分析101例经病理证实的乳腺癌患者(109个病灶)的超声和MRI资料;根据雌激素受体、孕激素受体、人表皮生长因子受体-2(HER-2)的表达状态,将乳腺癌分为三阴性、HER-2过表达和Luminal三个亚型,分析不同亚型乳腺癌超声和MRI表现。结果三种分子亚型乳腺癌病理分型差异有统计学意义(P<0.05);超声声像图中不同分子亚型乳腺癌的边界、边缘、是否钙化、血供程度及周围组织结构变化差异有统计学意义(P均<0.05);MRI中不同分子亚型乳腺癌平扫信号、边界、边缘、强化与否及强化方式和时间-信号强度曲线类型差异有统计学意义(P均<0.05)。结论不同分子亚型乳腺癌超声及MRI表现各具特点。

Objective To investigate the ultrasonic and MRI features of breast cancers of different molecular subtypes. Methods Ultrasonic and MRI data of 101 patients （109 lesions） with breast cancer confirmed by pathology were retrospectively analyzed. According to the expression of estrogen receptors, progesterone receptor and human epidermal growth factor receptor-2 （HER-2）, the tumors were classified into triple-negative, HER-2 over-expressed and Luminal subtypes. The ultrasonic and MRI features of breast cancers of different molecular subtypes were compared. Results There were statistical differences in pathological type among different molecular subtype breast cancers （P〈0.05）. The border, calcification, blood supply of tumor and the changes of surrounding tissue of tumors in ultrasonography, the signal intensity, border, intensify and time-signal intensity curve type in MRI were statistically different among breast cancer of different molecular subtypes （all P〈0.05）. Conclusion Ultrasonic and MRI features of different molecular subtypes breast cancers are different.