依达拉奉联合氯吡格雷治疗急性脑梗死的疗效观察

Clinical effect observation of the edaravone with clopidogrel in the treatment of acute cerebral infarction

目的探讨依达拉奉联合氯吡格雷治疗急性脑梗死的疗效,旨在为临床治疗方案的选择提供指导依据。方法回顾性分析我院住院治疗的急性脑梗死患者80例,全部患者均酌情予以降颅内压、营养脑细胞、控制血压血糖等对症支持治疗。其中应用常规对症支持治疗的40例患者设立为对照组,另外选择在同期对症治疗的基础上联合依达拉奉和氯吡格雷治疗的40例患者设立为对照组,观察组在上述处理基础上予以依达拉奉30mg加生理盐水250mL静滴,每日2次,氯吡格雷75mg,每日1次,口服。观察并比较两组的疗效及两组患者治疗前和治疗2周后神经功能改善情况。结果治疗2周后,观察组神经功能改善情况的总有效率明显优于对照组,差异有统计学意义(P<0.05)。治疗2周后,观察组及对照组的NIHSS分别为(26.34±7.23)、(27.75±8.79),均较治疗前明显降低,差异有统计学意义(P<0.05)。且观察组的NIHSS治疗2周后较对照组降低更显著,组间应用t检验进行处理,差异有统计学意义(P<0.05)。结论依达拉奉联合氯吡格雷治疗急性脑梗死具有较好的临床疗效,不良反应少,明显改善患者的预后,值得基层医院广泛推广和应用。

Objective To investigate the efficacy of edaravone with clopidogrel in the treatment of acute cerebral infarction,and to provide guidance for the clinical. Methods 80 cases with acute cerebral infarction were retrospectively analyzed and selected,the patients were all given intracranial pressure,nutrition brain cells,controlled blood pressure and blood sugar and other symptomatic and supportive treatment.40 patients in the control group were used conventional symptomatic and supportive treatmenton,at the same period,on the basis of the control group,40 patients in the observation group were given edaravone 30 mg plus 250 mL normal saline infusion,2 times a day, clopidogrel 75 mg once a day, orally.Compared the efficacy of the two groups/rod the nerve function improvement of two groups patients before treatment and after two weeks of treatment. Results After two weeks of treatment, the observation group nerve function improved significant than the control group, there had significant difference（P 〈 0.05）. After two weeks of treatment,the NIHSS of the observation group and the control group were （26.34 ± 7.23）,（27.75 ± 8.79） respectively,significantly lower than before treatment, there had significant difference（P 〈 0.05）.And the NIHSS of the observation group after treatment 2 weeks decreased more significantly than the control group,there were significant differences （P 〈 0.05）. Cgnclusion Edaravone with clopidogrel in the treatment of acute cerebral infarction have better clinical efficacy,little adverse reactions,significant improvement in the prognosis of patients,and it is worthy to use in primary hospital.