阿立哌唑与奎硫平治疗首发性精神分裂症的对照研究

Comparative study on aripiprazole and quetiapine in the treatment of first-episode schizophrenia

目的比较阿立哌唑与奎硫平对首发性精神分裂症的疗效及安全性。方法 80例首发性精神分裂症患者,随机分为阿立哌唑组(40例)和奎硫平组(40例),疗程8周。采用阳性和阴性症状量表(PANSS)、临床总体印象量表(CGI)及副反应症状量表(TESS),在治疗基线时及治疗第2、4、6、8周末分别评定疗效和副反应。结果(1)治疗第8周末,阿立哌唑组、奎硫平组临床总有效率分别为87.5%、85.0%,差异无统计学意义(P>0.05)。(2)治疗第2周末起,两组CGI-SI分较基线时下降(P<0.05);两组间各时点CGI-SI分比较差异无统计学意义(P>0.05);(3)阿立哌唑组、奎硫平组不良反应发生率分别为20.0%、22.5%,差异无统计学意义(P>0.05)。奎硫平组嗜睡、心率影响发生率高于阿立哌唑组。结论阿立哌唑及喹硫平治疗首发性精神分裂症疗效较好,不良反应轻,患者耐受性好,值得临床推荐使用。

Objective To compare the curative effect and safety of aripiprazole and quetiapine in the treatment of first-episode schizophrenia. Methods 80 cases of first-episode schizophrenia were randomly divided into aripiprazole group and quetiapine group,each group had 40 cases.A period of treatment was 8 weeks.The curative effect and side- effects were respectively evaluated at baseline and the 2nd, 4th, 6th and 8th week of treatment by using positive and negative syndrome scale（PANSS）,clinical global impression scale（CGI）and toxic effects symptoms scale（TESS）. Results （1）The clinical total effective rate of aripiprazole group and quetiapine group at the 8th week of treatment was 87.5%, 85.0% respectively,and the difference was not statistically significant（P 〉 0.05）.（2）Compared with baseline,the CGI-SI of two groups from the 2th week of treatment deereased（P 〈 0.05）; The difference was not significant in the CGI-SI at different time points between two groups（P 〉 0.05）;（3）The incidence of side-effects of aripiprazole group and quetiapine group was 20.0%,22.5% respectively,and the difference was not statistically significant（P 〉 0.05）. The incidence of drowsiness and heart rate of quetiapine group, were higher than those of aripiprazole group. Conclusion Aripiprazole and quetiapine in the treatment of first-episode schizophrenia have better curative effect,light adverse reaction,good tolerance,and it is worthy of clinical recommended use.