195个周期宫腔内人工授精结局的影响因素探讨

Intrauterine insemination: Analysis of the influencing factors in 195 cycles

目的:探讨影响夫精宫腔内人工授精妊娠率的因素。方法:回顾性分析2007年1月～2012年12月期间因不孕症行宫腔内人工授精(IUI)治疗的104对夫妇的195个周期。分析年龄、不孕年限、IUI治疗周期数、不孕原因、促排卵、成熟卵泡数目、子宫内膜厚度等因素和妊娠之间的关系。结果:单因素和多因素Logistic回归分析均表明继发性不孕症患者妊娠率更高(OR=3.494,P=0.032,OR=3.657,P=0.048)。与自然周期相比,促排卵周期成熟卵泡数目更多(OR=18.279,P=0.000),子宫内膜增厚(OR=0.186,P=0.007)。促排卵周期的妊娠率高于自然周期,有统计学意义(χ2=5.946,P=0.015)。结论:在IUI治疗中,选择合适的患者和促排卵治疗可提高妊娠率。

Objective： To investigate the influencing factors associated with the outcomes of pregnancy rate via intrauterine insemination（IUI） by husband’s donation.Methods： The data from 104 patients undergone IUI between Jan.2007 and Dec.2012 were retrospectively analyzed in 195 cycles（either natural or ovulation induction cycle）.The pregnancy outcomes were examined regarding the influencing factors including age,infertility time,cycles of IUI,causative infertility,ovulation induction,number of mature follicle and thickness of endometrium.Results： Univariate and multivariable regression logistic analysis revealed the pregnancy rate for patients with secondary infertility was higher than primery infertility（OR =3.494,P =0.032;OR = 3.657,P = 0.048）.The number of mature follicles were increased（OR = 18.279,P = 0.000） with thickened endometrium（OR = 0.186,P = 0.007） in women after ovulation induction as compared with those of natural cycles.The pregnancy rate in ovulation induction cycles was higher than that of nature cycles,it suggested significant difference（χ2 = 5.946,P = 0.015）.Conclusion： Rational determination of the patients and ovulation induction cycle may improve the pregnancy rate through IUI.