蛇毒降纤酶联合疏血通治疗急性脑梗死的临床观察

Clinical observation on treatment of acute cerebral infarction by snake venom fibrinolytic enzyme combined with Shuxuetong

目的观察蛇毒降纤酶与疏血通联合治疗急性脑梗死的疗效。方法选取2011年3月-2012年3月在本院住院的120例脑梗死患者，随机分为两组，在常规治疗的基础上，实验组给予蛇毒降纤酶10U，加入100ml生理盐水中静脉点滴，1次／d；疏血通注射液6ml，加入生理盐水250ml静脉滴注，1次／d。对照组给予疏血通注射液6ml，加入生理盐水250ml静脉滴注，1次／d，两组均连续用药14d。结果实验组总有效率为95．0％，对照组总有效率为76．7％，两组总有效率比较差异有统计学意义（P〈0．01）。治疗后实验组MRS评分、损伤神经功能及Barthel指数评分与对照组的差异有统计学意义（P〈0．01），实验组恢复情况明显好于对照组。结论蛇毒降纤酶联合疏血通治疗急性脑梗死安全有效，能提高临床疗效及患者生活能力。

Objective To observe the therapeutic effects of snake venom fibrinolytic enzyme combined with Shuxuetong on acute cerebra/infarction. Methods 120 patients with acute cerebral infarction hospitalized between March 2011 and March 2012 were randomly divided into two groups. Based on the conventional treatment, the experimental group also received the intravenous drip with 10 U snake venom fibrinolytic enzyme added into 100 ml normal saline once per day and also received the injection with 6 ml Shuxuetong added into 250 ml normal saline once per day. The control group only received the injection with 6 ml Shuxuetong added into 250 ml normal saline once per day. Both groups received the treatment continuously for 14 days. Results The total effective rate was 95.0% in the experimental group and 76.7% in the control group. There was significant difference in the total effective rate between the two groups （P 〈 0.01 ）. After the treatment, there were significant differences in MESSS scores, the indexes of the nerve function damage, and the Barthel index score between the two groups （P 〈 0.01 ）. The recovery of the experimental group was obviously better than that of the control group. Conclusion The combination treatment with snake venom fibrinolytic enzyme and Shuxuetong on acute cerebral infarction is safe and effective. It can improve the clinical curative effects and the patients＇viability.