高压氧联合依达拉奉和尼莫地平治疗急性一氧化碳中毒

HYPERBARIC OXYGEN COMBINED EDARAVONE AND NIMODIPINE IN THE TREATMENT OF ACUTE CARBON MONOXIDE POISONING

目的观察高压氧联合依达拉奉和尼莫地平治疗急性一氧化碳中毒的临床疗效。方法从我院收治入院的急性一氧化碳中毒患者抽取60例,随机分为观察组与对照组,对照组患者给予高压氧及纳洛酮、甘露醇等支持治疗,观察组患者在此基础上加入依达拉奉和尼莫地平的联合治疗。观察两组患者昏迷时间、临床疗效、迟发性脑病的发生情况、以及治疗期间不良反应的发生情况。结果观察组患者总有效率为93.33%(28/30),对照组为80.00%(24/30),观察组明显高于对照组;观察组患者平均昏迷时间为(4.02±1.77)h,对照组为(6.58±2.02)h,观察组明显短于对照组;观察组迟发性脑病发生率为3.33%(1/30),神经系统损伤发生率为3.33%(1/30),对照组分别为13.33%(4/30),16.67%(5/30),观察组明显低于对照组。上述数据对比差异显著(p<0.05),差异有统计学意义。治疗期间两组患者未出现明显的不良反应,对比无显著性差异(p>0.05)。结论高压氧联合依达拉奉和尼莫地平治疗急性一氧化碳中毒,临床疗效为理想,且迟发性脑病明显减少。

Objective To observe the clinical curative effect of hyperbaric oxygen combined with edaravone and ni-modipine in the treatment of acute carbon monoxide poisoning. Methods 60 cases from the acute carbon monoxide poisoning hospitalized patients were randomly divided into observation group and control group, the control group were treated with hy-perbaric oxygen and naloxone, mannitol treatment, the observation group were added edaravone and nimodpine combined treatment on the bases of control group. Observe the patients of two groups with the coma time, clinical efficacy, late enceph-alopathy, and occurrence of adverse reactions during the treatment. Results In the observation group, the total effective rate was 93.33% （28/30）, the control group was 80% （24/30）, the observation group was significantly higher than that of the control group; the mean duration of coma of patients in the observation group （4. 02 ± 1.77 ） h, while in the control group （6. 58 ± 2. 02 ） h, the observation group was shorter than the control group; the observation group delayed encephalopathy rate was 3.33% （ 1/30）, nervous system injury incidence was 3.33% （ 1/30）, the control group was 13. 33% （4/30）, 16. 67% （5/ 30）, the observation group was significantly lower than that of the control group. The comparison of the data the difference was statistically significant（p 〈 0. 05 ）. During the treatment two patient group without any obvious adverse reactions, no significant difference （p 〉 0. 05 ）. Conclusion Hyperbaric oxygen combined with edaravone and nimodipine in the treatment of acute car-bon monoxide poisoning, the clinical curative effect is ideal, and delayed encephalopathy significantly reduced.