大剂量地塞米松联合高压氧救治急性一氧化碳中毒的临床研究

Clinical Study of Large Dose of Dexamethasone Combined with Hyperbaric Oxygen in Treatment of Acute Carbon Monoxide Poisoning

目的:探讨大剂量地塞米松联合高压氧对一氧化碳中毒患者的疗效。方法:一氧化碳中毒患者60例,随机分为对照组30例和观察组30例,对照组给予高压氧治疗,观察组在高压氧基础上,给予大剂量地塞米松救治,观察两组的临床疗效。结果:两组患者均未出现严重并发症。治疗20d后,观察组总有效率为93.33%,高于对照组的63.33%(字2=7.36,P<0.05)。结论:早期、大剂量应用地塞米松抢救一氧化碳中毒有显著效果。

Objective： To investigate the effect of large dose of dexamethasone combined with hyperbaric oxygen in treatment of acute carbon monoxide poisoning.Method： 60 cases of carbon monoxide poisoning patients were randomly divided into control group （ 30 cases ） and observation group （30 cases ）, control group were given hyperbaric oxygen therapy, the observation group in the hyperbaric oxygen b^sis, were given treatment of large dose of dexamethasone, to observe clinical curative effects of two groups.Result： There was no severe complication in two groups of patients.20 days after treatment, to compare the clinical effect of the observation group and the control group, the total efficiency of the observation group was 93.33%, which was higher than 63.33% in the control group （X2=7.36, P〈0.05 ） . Conclusion： Early, large dose of dexamethasone treatment has obvious effect of carbon monoxide poisoning.