重度子痫前期合并脑静脉血栓的相关性研究

Research on the Relevance of Severe Preeclampsia Complicated by Cerebral Venous Thrombosis at Early Stage

目的:探讨重度子痫前期合并脑静脉血栓(CVT)形成的相关因素与疗效分析。方法:给予本院34例重度子痫前期合并CVT患者脱水、抗凝治疗,同时给予激素治疗23例,给予肝素或低分子素治疗28例,尿活素静脉窦内置管接触性溶栓20例,全部患者给予华法林口服,进行抗凝血治疗。结果:本组治疗后的总有效31例(91.18%),3例无效均为视力未恢复正常。发病相关因素有子痫前期毛细血管受损而组织液外溢13例(38.24%)、产后长时间卧床10例(29.41%)、产后大量出汗7例(20.59%)、发病前未进行防治血栓措施4例(11.76%)。4个月后复查,2例患者部分再通,其余均完全康复。结论:早期给予重度子痫前期并CVT患者抗凝、溶栓治疗,可得到很好的预后。

Objective： To research into the relevant factors and treatement effects of severe preeclampsia complicated by cerebral venous thrombosis （ CVT ） at early stage.Method： Treated 34 cases of severe preeclampsia complicated CVT at early stage with dehydration and anticoagulation, and in the same time 23 cases were treated with hormone, 28 cases were given heparin or low molecular weight heparin, while 20 cases were given contact thrombolytic therapy through Urokinase intravenous catheter. All patients were given oral warfarin for anticoagulation therapy. Result： In this group there were totally 31 effective cases （ 91.18% ）, and 3 cases were ineffective and eyesight did not recover.Etiologic factors included 13 cases （ 38.24% ） of tissue fluid overflow caused by capillary damage at early stage of preeclampsia, 10 cases （ 29.41% ） of long postpartum bed confinement, 7 cases （ 20.59% ） of postpartum diaphoresis and 4 cases （ 11.76% ） of absence of thrombosis prevention measures before attack.Review after 4 months showed that 2 patients had partial recanalization and others all fully recovered. Conclusion： Treating severe preeclampsia complicated by CVT patients with anticoagnlation and thrombolytic therapy can achieve good prognosis.