毛细支气管炎后支气管哮喘发生的相关因素分析

Factors Associated with the Occurrence of Asthma after Bronchiolitis

目的:分析和探究毛细支气管炎后发生支气管哮喘的相关因素。方法:选取本院就诊的84例毛细支气管炎患儿为研究对象,对其临床资料进行统计、分析(包括患者的年龄、性别、病情、病原学及过敏原检测等),患儿出院后对患儿的呼吸道感染以及气管哮喘的发作情况进行随访、诊断,根据患儿是否发生支气管哮喘,采用Logistic回归分析方法分析可能引起支气管哮喘的因素以及这些因素与支气管哮喘发病的相关程度。结果:84例毛细支气管炎患儿在出院后5年内,有32例发生了支气管哮喘。发病(支气管哮喘)组与非发病组进行多因素比较,患儿的哮喘家族史,反复的下呼吸道感染,患毛细支气管炎时患儿的年龄、病情等方面差异均具有统计学意义(P<0.05)。可以说这些因素共同影响着支气管哮喘的发生。而患儿的性别、居住环境等因素均与支气管哮喘的发生无明显的相关性。结论:患者毛细支气管炎的病情程度严重、伴有哮喘家族史、患有湿疹和其他的下呼吸道感染等是毛细支气管炎后发生支气管哮喘的主要危险因素。

Objective： To analyze and study the related factors of bronchial asthma after hronchiolitis.Method： 84 cases underwent bronchiolitis treatment as the object of study, statistics, analysis of the clinical data （ content statistics, analysis include age, gender, disease, etiology and allergen detection ）, follow-up, diagnosis for the children＇s respiratory tract infection and onset of bronchial asthma of children after leaving hospital, according to whether the occurrence of asthma in children, using Logistic statistical analysis might lead to bronchial asthma factors and these fa6tors and bronchial asthma related degree was analyzed.Result： 84 cases of capillary bronchitis patients in five years after discharge, there were 32 cases with bronchial asthma. Disease （ asthma ） group and non onset group multiple factors in children with asthma, family history, lower respiratory tract recurrent infections, with bronchiolitis children age, illness, there were significant differences （ P〈0.05 ） . It could be said that these factors affect the incidence of bronchial asthma. And the child＇s gender, living environment and other factors and the incidence of bronchial asthma had no obvious correlation.Conclusion： Patients with bronchiolitis severity, family history of asthma, accompanied by severe eczema and other LRTI are the main risk factors of bronchial asthma after bronchiolitis.