维持性血液透析患者发生心血管疾病危险因素分析

Risk factors for cardiovascular disease in maintenance hemodialysis patients

目的:探讨维持性血液透析患者血尿酸(UA)水平与心血管疾病(CVD)的相关性,以及发生CVD的危险因素。方法:选取97例维持性血液透析患者,根据有无合并CVD并发症分为2组,回顾性收集研究对象的临床资料并利用单因素和多因素模型分析数据。结果:CVD组患者血UA水平明显高于无CVD组(P<0.01),且2组患者的透析时间、空腹血糖、平均动脉压(MBP)、总胆固醇(TC)水平差异有统计学意义(P<0.01);logistic回归分析显示,患者血UA、MBP、TC水平与CVD的发生均呈正相关关系(P<0.05～P<0.01)。结论:维持性血液透析患者的血UA、MBP、TC水平是CVD发生的独立危险因素。

Objective： To investigate the relationship between the uric acid and cardiovascular diseases（CVD） in patients receiving maintenance hemodialysis,and the risk factors for CVD.Methods： Ninety-seven maintenance hemodialysis patients were divided into CVD group and non-CVD group.The clinical data were collected retrospectively and analyzed with univariate and multivariate models to find out the risk factors for CVD.Results： The level of serum uric acid in CVD group was significantly higher than that in non-CVD group（P 0.01）,and the duration of dialysis,fasting plasma glucose,mean arterial blood pressure（MBP） and total cholesterol（TC） levels were significantly different between the two groups（P 0.01）;logistic regression analysis showed that the uric acid,MBP and TC level were positively correlated with the incidence of CVD（P 0.05-P 0.01）.Conclusions： In maintenance hemodialysis patients,the serum uric acid,MBP and TC levels are independent risk factors for CVD.