吸烟对广州市海珠区社区居民血脂和尿酸水平的影响

The effects of cigarette smoking on blood lipid and serum uric acid in community-dwelling residents at Haizhu district in Guangzhou

目的了解吸烟对广州社区居民血脂、尿酸水平的影响。方法选取2009年广州市海珠区高血压流行病学研究的人群中有吸烟情况、血脂、血尿酸等完整资料者,比较不同吸烟状况居民的血脂、血尿酸水平。结果在广州市海珠区高血压流行病学研究的人群中,有吸烟情况、血脂、血尿酸等完整资料者共2 149名,其中男842名,女1 307名;从不吸烟者1 669名,吸烟者387名,93名已戒烟;吸烟者TG明显高于从不吸烟者(P<0.01),HDL-C及ApoA、ApoA/ApoB比值均明显低于从不吸烟者(P<0.01),吸烟对TC、LDL-C以及ApoB无明显影响(P>0.05)。吸烟量对血压、血脂水平无显著影响,吸烟量≥20支/d的居民ApoA水平有降低趋势(P=0.055)。从不吸烟者的血尿酸水平明显低于吸烟及戒烟者(P<0.01)。结论血HDL-C降低和尿酸升高可能与吸烟导致心血管疾病有关。

Objective To investigate the effects of cigarette smoking on blood lipid and serum uric acid in community-dwelling residents in Guangzhou.Methods The data were extracted from the epidemiological investigation of hypertension at Haizhu district of Guangzhou.The residents with complete data of cigarette smoking information,blood lipid and serum uric acid were selected.The effects of cigarette smoking on blood lipid and serum uric acid were analyzed.Results A total of 2149 residents（842 males and 1307 females） were included,among whom there were 1669 non smokers,387 smokers and 93 ex-smokers.The serum triglyceride of smokers was significantly higher than that of non smokers（P 0.01）,while the serum high-density lipoprotein cholesterol（HDL-C）,apolipoprotein A（ApoA） and the ratio of ApoA to ApoB were significantly lower than that of non-smokers（P 0.01）.However,cigarette smoking did not affect the serum total cholesterol,low-density lipoprotein cholesterol（LDL-C） and ApoB（P 0.05）.The serum uric acid of non-smokers was significantly lower than those of smokers and ex-smokers.Conclusion Decrease of serum HDL-C and increase of uric acid are correlated to cigarette smoking-induced cardiovascluar disease.