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影响颈动脉硬化及斑块形成的相关因素 被引量:9

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摘要 目的探讨影响颈动脉硬化及斑块的危险因素,为该病的预防提供循证医学依据。方法选取1 756健康体检人员按其颅外段颈动脉的超声检查结果,分为正常对照组、颈动脉斑块组、颈动脉硬化组,分别检测血压、胆固醇、三酰甘油、低密度脂蛋白、高密度脂蛋白、尿酸、空腹血糖、餐后2 h血糖、糖化血红蛋白、13碳呼气试验等指标,先进行单因素卡方检验,再应用多元逻辑回归的统计方法对各因素作相关分析。结果单因素2检验结果表示:性别、脂肪肝、总胆固醇、高密度脂蛋白、低密度脂蛋白这5项结果在各组间比较差异有统计学意义(P<0.05)。多元逻辑回归分析筛选出4个影响因素分别是:脂肪肝、总胆固醇、高密度脂蛋白、低密度脂蛋白,性别、年龄可能与动脉硬化有关(P<0.05)。总模型拟合度R2=0.696,即69.6%的数据精确符合本模型。结论脂肪肝、总胆固醇、高密度脂蛋白、低密度脂蛋白是单独影响颈动脉斑块、颈动脉硬化的因素。临床上应对以上因素做出针对性预防干预措施,防止患者发生颈动脉硬化和颈动脉斑块形成。
作者 马立宇 邹菱
出处 《广东医学》 CAS CSCD 北大核心 2013年第16期2514-2516,共3页 Guangdong Medical Journal
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