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血浆(1-3)-β-D-葡聚糖对侵袭性真菌感染诊断价值的荟萃分析

Plasma(1-3)-β-D-Glucan Assayin the Diagnosis of Invasive Fungal Infections:A Meta-analysis
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摘要 目的采用荟萃分析评价血浆(1,3)-β-D-葡聚糖检测对侵袭性真菌感染的诊断价值。方法采用STATA11软件分析纳入研究项目血浆(1,3)-β-D-葡聚糖浓度诊断侵袭性真菌感染总的灵敏度、特异度,阳性似然比和阴性似然比。结果纳入的31组研究数据分析显示总的灵敏度,特异度,阳性似然比和阴性似然比分别为0.79(95%CI,0.73~0.85),0.86(95%CI,0.80~0.90),5.64(95%CI,3.818~8.352),和0.242(95%CI,0.179~0.326)。结论荟萃分析显示血浆(1,3)-β-D-葡聚糖检测对于诊断IFI有较高的临床价值。 Objective To explore the overall accuracy of plasma (1-3 )-β-D-glucan assay for diagnosing of invasive fungal infections (IFI) with a meta: analysis. Methods The sensitivity, specificity, and positive and negative likelihood ratios of (1-3)-β-D-glucan in the diagnosis of IFI were pooled using a bivariate meta-analysis with STATA 11. Results Thirty- one studies were included for the analysis ( proven, probable, and possible IFI vs no IFI). The pooled sensitivity, specificity, PLR and NLR were 0.79 (95% CI, 0. 73-0. 85 ) , 0.86 (95% CI, 0. 80-0. 90) , 5.64 (95% CI, 3. 818-8. 352), and 0. 242 (95% CI, 0. 179-0.326), respectively. Conclusion Plasma (1-3)-β-D-glucan assay is clinically useful for diagnosing IFI in at-risk patients.
出处 《标记免疫分析与临床》 CAS 2013年第4期239-242,共4页 Labeled Immunoassays and Clinical Medicine
关键词 葡聚糖 侵袭性真菌感染 荟萃分析 Gluean Invasive fungal infections Metaanalysis
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参考文献11

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