阿托伐他汀联合替米沙坦对糖尿病肾病患者血清TGF—β1、CTGF的影响

Effect of Atorvastatin Combined with Telmisartan on Serum TGF-β1 and CTGF of Patients with Diabetic Nephropathy

【目的】探讨阿托伐他汀联合替米沙坦对2型糖尿病肾病（DN）患者血清转化生长因子-β1（TGF-β1）和结缔组织生长因子（CTGF）的影响。【方法】将80例DN患者随机分为观察组和对照组各40例，对照组给予替米沙坦治疗，观察组给予阿托伐他汀联合替米沙坦治疗，12周后分析比较两组患者的平均动脉血压（MAP）、血总胆固醇（TC）、血甘油三脂（TG）、血肌酐（SCr）、血尿素氮（BUN）、尿白蛋白排泄率（UAER）及血清TGF-β1、CTGF水平。【结果】两组患者的MAP、SCr、BUN、UAER、TGF-β1及CTGF水平均较治疗前降低，差异有统计学意义（P〈O．05）；观察组TC、TG水平也较治疗前明显下降（P〈O．05），且其TC、TG、SCr、BUN、UAER及TGF-β1水平改善优于对照组（P〈O．05）。【结论】阿托伐他汀联合替米沙坦治疗DN疗效显著，通过降低血清TGF-β1、CTGF水平可能是其肾脏保护作用的机制之一。

[ObjectivelTo explore the effect of atorvastatin combined with telmisartan on serum transfer growth factor beta 1 （TGF-β1） and connective tissue growth factor（CTGF） of type 2 diabetic nephropathy （DN） patients. [MethodslTotally 80 DN patients were randomly divided into observation group and control group with 40 cases in each. The control group was given telmisartan treatment, while the observation group was given atorvastatin combined with telmisartan treatment. After 12 weeks, the mean arterial blood pressure （MAP）, serum total cholesterol（TC）, blood triglyceride（TG）, serum creatinine（Scr）, blood urea nitrogen （BUN）, urinary albumin excretion rate（UAER） and serum levels of TGF-β1 and CTGF of two groups were analyzed and compared. [ResultslCompared with before treatment, the levels of MAP, Scr, BUN, UAER, TGF-β1 and CTGF in patients of two groups decreased, and there were significant differences（ P 〈0.05）. Compared with before treatment, the levels of TC and TG in observation group obviously decreased（ P〈0.05）, and the improvement of levels of TC, TG, Scr, BUN, UAER and TGF-β1 in observation group was better than that in control group（ P 〈0.05）. [ConclusionlThe curative effect of atorvastatin combined with telmisartan for the treatment of DN is significant. One of the mechanisms of renal protective effect is through lowering the serum levels of TGF-β1 and CTGF.