右美托咪啶在临床麻醉中应用研究进展被引量：6

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摘要右美托咪啶属于一种高效以及高选择性的α2肾上腺素能受体激动剂,主要产生镇痛与镇静等方面的功能作用,以其高临床功效而得到了较为广泛的应用,已经在神经外科手术麻醉、儿科麻醉、心外科等领域获得了较为成功的应用。本文主要对右美托咪啶的临床应用进展进行了综述,旨在为右美托咪啶在临床麻醉的应用提供一定的依据。

作者刘彦

机构地区天津市职业病防治院(工人医院)麻醉科

出处《青岛医药卫生》 2013年第4期286-287,共2页 Qingdao Medical Journal

关键词右美托咪啶神经外科手术儿科麻醉脑功能区唤醒麻醉

分类号 R971 [医药卫生—药品]

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参考文献8

1Kamibayashi T, Maze M. Clinical uses of alpha 2-adrenergic agonists [J]. Anesthesiology, 2000, 93:1345 -1350.
2Nelson LE, Lu J, Guo TZ, et al. The a2 Adrenoceptor ago- nist dexmedetomidine converges on an endogenous sleep-pro- moting pathway to exert its sedative effects[J]. Anesthesiolo- gy, 2003,98:428-436.
3许挺,李民.右美托咪啶在功能神经外科手术麻醉中的应用[J].中国新药杂志,2010,19(13):1128-1130. 被引量：51
4Mason KP, O' Mahony E, et al. Effects of dexmedetomidine sedation on the EEG in children[J]. Paediatr Anaesth, 2009, 19(12):1175 -1183.
5Vilo S, Rautianen P, Kaisti K, et al. Pharmacokinetics of in- travenous dexmedtomidine in children under 11 yr of age[J]. Br J Anaesth, 2008, 100(5) :697-700.
6闫诺,杨程,陈宁.氯胺酮复合右旋美托咪啶静脉麻醉在小儿脑立体定向术中的应用[J].武警医学院学报,2011,20(7):558-559. 被引量：7
7Furst SR, Weinger MB. Dexmedetomidine, a selective alpha 2 agonist, does not potentiate the cardiorespiratory depression of alfentanil in the rat [J]. Anesthesiology, 1990, 72 (5) : 882- 888.
8Barletta JF, Midedema SL. Impact of dexmedetomidine on an- algesic requirements in patients after cardiac surgery in a fast track recovery room setting[J]. Pharmacotherapy, 2009, 67 (9) : 1427-1432.

二级参考文献18

1李民,张利萍,吴新民.右美托咪啶在临床麻醉中应用的研究进展[J].中国临床药理学杂志,2007,23(6):466-470. 被引量：483
2ROZET I. Anesthesia for functional neurosurgery:the role of dexmedetomidine [ J ]. Curr Opin Anaesthesiol, 2008, 21 ( 5 ) : 537 - 543.
3COULL JT, JONES ME, EGAN TD, et al. Attentional effects of noradrenaline vary with arousal level: selective activation of thalamic pulvinar in humans [ J ]. Neuro Image, 2004, 22 ( 1 ) : 315 -322.
4BILOTTA F, ROSA G. ' Anesthesia' for awake neurosurgery [J]. Curr Opin Anaesthesiol, 2009, 22(5):560-565.
5HALL JE, UHRICH TD, BARNEY JA, et al. Sedative, amnestic, and analgesic properties of small-dose dexmedetomidine infusions[J]. Anesth Analg, 2000, 90(3):699-705.
6EBERT TJ, HALL JE, BARNEY JA, et al. The effects of increasing plasma concentrations of dexmedetomidine in humans [ J ]. Anesthesiology,2000, 93 ( 2 ) : 382 - 394.
7BEKKER AY, KAUFMAN B, SAMIR H, et al. The use of dexmedetomidine infusion for awake craniotomy [ J ]. Anesth Analg, 2001, 92(5) :1251 - 1253.
8SOUTER MJ, ROZET I, OJEMANN JG, et al. Dexmedetomidine sedation during awake craniotomy for seizure resection effects on electrocorticography[ J]. Neurosurg Anesthesiol, 2007 19(1) :38 -44.
9TALKE P, STAPELFELDT C, GARCIA P. Dexmedetomidine does not reduce epileptiform discharges in adults with epilepsy [ J ]. J Neurosurg Anesthesiol, 2007, 19 (3) : 195 - 199.
10ARD JL JR, BEKKER AY, DOYLE WK. Dexmedetomidine in awake craniotomy: a technical note[ J 1. Surg Neurol, 2005, 63 (2) :114 -117.