血管紧张素转化酶基因的插入/缺失多态性与心肌梗死的关系

Association between the insertion/deletion polymorphism of angiotensin converting enzyme gene and the myocardial infarction

目的 探讨国人血管紧张素转化酶 (ACE)基因的插入 /缺失 (I/D)多态性与心肌梗死的关系。方法 应用多聚酶链反应方法检测 ACE基因多态性。结果 心肌梗死患者 ACE基因 DD型频率 (0 .38)及 D等位基因频率 (0 .5 8)均明显高于对照组。结论 国人ACE基因 DD型与心肌梗死有关 ,可能是发生心肌梗死的重要危险因素之一。

Objective To investigate the association between the insertion/deletion(I/D) polymorphism of angiotensin converting enzyme (ACE) gene and the myocardial infarction (MI) among Chinese population. Methods Polymerase chain reaction(PCR) was applied to the examination of ACE gene polymorphism. A comparison was performed between 50 patients with MI and another 50 healthy subjects.Results The frequencies of DD genotype (0.38) and D allele (0.58) were both higher among the MI group than that among the control group (0.16 and 0.41 respectively,P<0.05).Conclusion The ACE/DD genotype is associated with MI morbidity,which might be an important risk factor for MI among the Chinese population.