化疗对男性急性白血病患者精液质量的影响

Effect of chemotherapy on semen quality in male acute leukemia patients

目的探讨化疗对男性急性白血病患者精液质量的影响。方法回顾2012年1-12月在解放军总医院生殖医学中心留取精液的化疗后男性急性白血病患者14例,同期抽取同院生殖医学中心体检的正常生育力男性40例,按《世界卫生组织人类精液检查与处理实验室手册》(第五版)进行精液常规检测,评估精子浓度、前向运动(progressive motility,PR)精子百分率。结果 10例精液未见精子,4例精子浓度均数及PR精子百分率均数较正常组明显降低,化疗后男性组的精子浓度均数(0.94×106/ml)、PR精子百分率均数(4.07%)与正常生育力男性组的精液参数间的差异有统计学意义(P均<0.01)。结论化疗药物会导致精液中精子质量下降,故在进行化疗之前应关注男性生殖力的保护。

Objective To study the effect of chemotherapy on semen quality in male acute leukemia patients.Methods Semen samples were taken from 14 acute leukemia patients who underwent chemotherapy in Chinese PLA General Hospital from January 2012 to December 2012 and from 40 male controls with normal fertility.The concentration and progressive motility rate of their sperms were measured according to the WHO Laboratory Manual for Sperm Examination and Processing of Human Semen.Results No sperm was detected in semen from 10 patients.The mean number and progressive motility rate of sperms were 0.94×106/mL and 4.07%,respectively,in 4 patients,which were significantly lower than those in male controls with normal fertility（P0.01）.Conclusion Since chemotherapy can reduce the quality of sperms in semen of male acute leukemia patients,their fertility should thus be protected before chemotherapy.