肾康灵对小儿频复发性肾病血栓素A_2、前列环素及皮质醇的影响

Clinical effects of Shenkangling on thromboxane A 2,prostacyclin and cortisol of frequently recurrent nephritic syndrome in children

目的观察肾康灵对小儿频复发性肾病(FRNS)血栓素A2(TXA2)、前列环素(PGI2)及皮质醇的影响。方法将FRNS患儿50例,随机分为对照组和治疗组各25例,对照组采用常规治疗,治疗组采用肾康灵+常规治疗,比较治疗前和治疗后6个月皮质醇、24 h尿蛋白定量、血浆总蛋白、白蛋白、血和24 h尿TXA2、PGI2的代谢产物TXB2和6-酮-前列腺素F lα(6-keto-PGF lα)等相关指标的变化。结果治疗组皮质醇、血和24 h尿TXB2、6-keto-PGF lα显著优于对照组且差异具有统计学意义(P<0.05);两组治疗后血和24 h尿TXB2/6-ketoPGF lα值均优于治疗前(P<0.05),治疗后治疗组也优于对照组(P<0.05)。结论肾康灵治疗FRNS能够调节皮质醇、纠正TXA2/PGI2失衡和降低复发率。

Objective To observe the clinical effects of Shenkangling on thromboxane A2 , prostacyclin and cortisol of frequently re- curreent nephritic syndrome （FRNS） in children. Methods 50 cases of FRNS were collected and divided randomly into two groups, control group and treatment group. Each group was with 25 cases. The treatment group was treated with conventional therapy together with Shenkangling; as a comparison, the control group was treated with conventional therapy only. The varieties of cortisol, 24h urinary protein, serum total protein, albumin, blood and urine TXA2 , 24h, PGI2 metabolites thromboxane B2 and 6-keto pros- taglandin F1α （6-keto PGF1α ） and other related indicators were compared before and 6 months later of the treatment. Results Blood cortisol,urinary 24h TXB2and 6-keto-PGF1αindexes of the treatment group were significantly improved compared with its control group counterpart. The differences showed statistical significance （P 〈 0.05） can be observed. After treatment, both blood, urine TXB2/6-keto-PGF1α 24h values and blood TP, ALB, 24 hour urinary protein quantitative values of two groups were improved than before （P 〈 0.05 ）. The treatment group showed better treatment effect in the indicators above than the control group （P 〈 0.05 ）. Conclusion Shenkangling can be effectively used in treatment of FRNS to regulate cortisol, corrective TXA2/PGI2 imbalances and reduce the relapse rate. Its application need be further studied.