地佐辛联合丙泊酚对胆囊切除患者应激反应的影响

Dezocine Combined with Propofol on Stress Response in Patients with Cholecystectomy

目的探讨地佐辛联合丙泊酚对胆囊切除患者应激反应的影响。方法 92例胆囊手术治疗的患者作为研究对象,观察组46例,对照组46例,观察组采用地佐辛联合丙泊酚麻醉,对照组采用芬太尼联合丙泊酚麻醉。测定麻醉诱导前(T0)、手术45min(T1)、术后1d(T2)时血清皮质醇(Cor)和超敏C反应蛋白(hs-CRP)。结果观察组麻醉有效率95.7%;对照组麻醉有效率93.5%。两组间比较无明显差异(χ2=0.78,P>0.05)。在T0时两组血清Cor和hs-CRP无明显差异(P>0.05),在T1和T2时,观察组血清Cor和hs-CRP明显低于对照组。结论地佐辛联合丙泊酚可以明显减轻胆囊切除患者的应激反应。

Objeetive To study dezocine combined with propofol on stress response in patients with cholecystectomy.Methods 92 patients with cholecystectomy were randomly divided into two groups,the observation group（n=46 cases） and the control group（n=46 cases）.The patients in the observation group were anesthetized through dezocine combined with propofol,while the patients in the control group were anesthetized through fentanyl combined with propofol. Serum cortisol （Cor） and high-sensitivity C-reactive protein （hs-CRP） were measured before induction of anesthesia （T0）,surgery for 45 minutes （T1） and postoperative ld （T2）.Rsults Anesthesia effieiencies were 95.7% in the observation group and 93.5% in the control group. No significant difference between the two groups （2＇2=0.78,P〉0.05）. TO serum Cor and hs-CRP was no significant difference （P〉0.05） in T1 and T2, serum Cor and hs-CRP in the observation group were significantly lower than the control group.Conclusions Dezocine combined with propofol can decrease stress response in patients with cholecystectomy.