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曲马多对于癌性疼痛的治疗作用 被引量:5

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摘要 采用麻醉性镇痛药或者添加辅助用药可以有效改善大部分癌症患者的疼痛。弱阿片类药物通常推荐用于中性癌性疼痛,但是否适用于WHO推荐的镇痛阶梯治疗中的第二步治疗仍有争议。基于实验及文献,我们认为弱阿片类药物用于中度癌性疼痛治疗作用非常明确。曲马多是弱阿片类药物中非常有趣及有效的一种药物。对于它独特的作用机制、止疼效果和副作用已进行了大量实验和临床研究。本文我们从药理、作用机制、副作用和临床经验来评估曲马多对于癌性疼痛的镇痛效果、副作用及安全性。
机构地区 武警
出处 《中国医药指南》 2013年第22期782-784,共3页 Guide of China Medicine
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  • 1Leppert W,Luczak J,Oliver D.Tramadol and cancer pain[J].Eur JPalliat Care,2002,9(2):49–51.
  • 2Hennies MH,Friderichs E,Schneider J.Receptor binding,analgesicand antitussive potency of tramadol and other selected opioids[J].Arzneimittelforschung,1988,38(7):877–880.
  • 3Barnung SK,Treschow M,Borgbjerg FM.Respiratory depressionfollowing oral tramadol in a patient with impaired renalfunction[J].Pain,1997,71(1):111–112.
  • 4Bianchi M,Rossoni G,Sacerdote P,et al.Effect softramadol on experimental inf lammation[J].Fundam ClinPharmacol,1999,13(2):220–225.
  • 5Memis D,Turan A,Karamanlioglu B,et al.The prevention of propofol injection pain by tramadol or ondansetron[J].Eur JAnaesth,2002,19(1):47–51.
  • 6Lintz W,Barth H,Osterloh G,et al.Bioavailability of enteral tramadolformulations[J].Arzneimittelforschung,1986,36(8):1278–1283.
  • 7Lee CR,McTavish D,Sorkin EM.Tramadol—a preliminary reviewof its pharmacodynamic and pharmacokinetic properties,andtherapeutic potential in acute and chronic pain states[J].Drugs,1993,46(2):313–340.
  • 8Valle M,Garrido M J,Pavon J M,et al.Pharmacokinet ic-pharmacodynamic modelling of the antinociceptive effects ofmain active metabolites of tramadol,(+)-O-desmethyltramadoland(-)-O-desmethyltramadol in rats[J].J Phar macol ExpTher,2000,293(2):646–653.
  • 9Cicero JC,Adams EH,Geller A,et al.A postmarketing surveillanceprogram to monitor Ultram(tramadol hydrochloride)abuse inthe United States[J].Drug Alcohol Depend,1999,57(1):7–22.
  • 10Pang WW,Wu HS,Lin CH,et al.Metoclopramide decreasesemesis but increases sedation in tramadol patient-controlledanalgesia[J].Can J Anesth,2002,49(10):1029–1033.

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