阿魏酸药动学研究进展

Research progress in pharmacokinetic study on ferulic acid

阿魏酸是广泛存在于植物中的一种功能性酚酸,也是当归、升麻、川芎等常用中药的主要活性成分。它具有很强的抗氧化和抗炎活性,能有效提高血流量、抑制血小板聚集、降低血脂水平、抑制血栓形成,可用于心血管疾病的治疗。通过查阅整理文献,对阿魏酸药动学研究进行综述,包括阿魏酸作为咖啡酸代谢物的药动学研究、阿魏酸的吸收动力学研究、阿魏酸的代谢和排泄研究、以及阿魏酸临床用药安全性研究,为临床合理应用及给药方案的确定提供科学依据。

Ferulic acid is a functional phenolic acid widely found in plants and also the major active component in Angelicae Sinensis Radix, Cimicifugae Rhizoma, and Chuanxiong Rhizoma. Ferulic acid presents the strong anti-oxidant activity and anti-inflammatory activity can significantly improve the blood fluidity and reduce the serum lipids, inhibit the platelet aggregation, and thrombus formation, and is effective for the treatment of cardiovascular diseases. In this paper, large number of literatures were consulted and the pharmacokinetic study on ferulic acid was reviewed to provide the scientific support for the clinical medication of ferulic acid. This paper was processed in four main parts, including the pharmacokinetic study on ferulic acid as the metaholite of caffeic acid, the absorption research on ferulic acid, the metabolism and excretion of ferulic acid, and safety study on ferulic acid in clinic.