糖尿病足溃疡伴发外周动脉病变相关危险因素分析

Analysis of relative risk factors of patients with diabetic foot ulcer combined with peripheral arterial disease

目的分析糖尿病足溃疡（DFU）患者伴发外周动脉病变（PAD）的危险因素。方法回顾性分析21I例住院DFU患者的临床资料，根据有无下肢动脉缺血分为缺血性溃疡（Iu）组（136例）以及非缺血性溃疡（NIU）组（75例），分析DFU伴发PAD的危险因素。结果单因素分析表明，年龄、糖尿病病程、吸烟、合并冠心病、足溃疡时间、三酰甘油、低密度脂蛋白胆固醇、空腹血糖（FPG）、餐后2h血糖、载脂蛋白（Apo）A．和ApoB、糖化血红蛋白（HbA．c）、收缩压、c反应蛋白是DFU伴发PAD的危险因素（P〈0．01或〈0．05）。多因素Logistic回归分析显示，年龄（OR=0．983，P=0．006）、合并冠心病（OR=4．800，P=0．001）、FPG（OR=1．153，P=0．001）、HbA。C（OR=0．798，P=0．001）是DFU患者伴发PAD的独立危险因素。结论伴发PAD的DFU患者病变程度重，伴发病多。年龄、合并冠心病、FPG、HbA．C是DFU患者伴发PAD的重要危险因素。

Objective To investigate the clinical characteristics and risk factors of peripheral arterial disease（PAD）in patients with diabetic foot ulcer（ DFU ）. Methods Two hundred and eleven hospital patients with DFU were enrolled and divided into is chemic ulcer （IU） group （ 136 patients, with PAD） and non-IU group（ 75 patients, without PAD ）. The clinical characteristics were retrospectively analyzed. Results Single factor analysis showed that age, the course of diabetes mellitus, smoking, accompanied with coronary artery disease, the course of DFU, triacylglycerol, low-density lipoprotein cholesterol, fasting plasma glucose （ FLaG ）, post-prandial 2 h blood glucose, apoprotein（ Apo）A1 and ApoB, glycosylated hemoglobin （ HbA1c ）, systolic blood pressure, C-reactive protein were risk factors （P 〈 O.Ol or 〈 0.05 ）. Multiple factors Logistic regression showed that age（ OR = 0.983, P = 0.006）, accompanied with coronary artery disease（ OR = 4.800, P=0.001）,FPG （OR = 1.153,P= 0.001 ）,HbAic （OR=0.798,P= 0.001） were important risk factors of DFU. Conclusions The degree of lesion in DFU combined with PAD is more seriously and associated disease axe more. Age ,accompanied with coronary artery disease, FlaG, HbAic axe the important risk factors of DFU combined with PAD.