异甘草酸镁注射液联合伐昔洛韦、红光治疗仪治疗带状疱疹临床观察

Clinical observation on treating herpes zoster with magnesium isoglycyrrhizinate injection combined with valaciclovir, red light therapy device

目的:探讨异甘草酸镁联合伐昔洛韦、红光治疗仪治疗带状疱疹的疗效。方法:选择符合标准的88例带状疱疹患者,随机分为治疗组和对照组。对照组口服伐昔洛韦、红光治疗仪病灶部位照射,疗程10d,治疗组在对照组治疗基础上加用异甘草酸镁注射液静滴,疗程7d。两组患者治疗期间均每日临床观察,并记录止疼、止疱及结痂情况,疗程结束后每周随访2次,共6次。结果:治疗组的止疱、止痛、结痂时间与对照组比较差异有统计学意义(P均<0.01)。两组治疗7d时有效率比较,差异有统计学意义(x2=4.67,P<0.05)。结论:异甘草酸镁注射液联合伐昔洛韦、红光治疗仪治疗带状疱疹,能够缩短止痛、止疱及结痂时间并提高疗效,且安全、可靠不良反应较小。

Objective： To investigate the curative effect on herpes zoster by using magnesium isoglycyrrhizinate injection combined with valaciclovir, red light therapy device. Methods： 88 cases of herpes zoster who all meet the standards were divided into treated group and control group. The control group was treated with valacyclovir orally and irradiated lesion site by red light therapy device, treated for 10 days. While the treated group was treated with additionally magnesium isoglycyrrhizinate based on the therapeutic method of the control group, treated for 7 days. To take notes about the changes of pain relief, blisters fade and scab every day. After the treatment, two times follow-up per week, a total of 6 times. Results： The treated group compared with the control group, it has significant difference in reducing the time of pain relief, blisters fade and scab （P〈0.01）. Efficiency at 7 days after treatment, the difference was statistically significant （x2= 4.67, P〈0.05）. Conclusion： When using the way of magnesium isoglycyrrhizinate combined with valaciclovir, red light therapy device, it can shorten the pain, blisters and scabs time and improve efficacy, sure, the method is also safe, reliable and fewer adverse reactions.