发作间期癫痫患者自然睡眠脑电图与常规清醒脑电图的对比分析

Comparative analysis of natural sleep electroencephalogram and routine awake electroencephalogram in the diagnosis of interictal epilepsy

目的探讨自然睡眠脑电图(EEG)对发作间期癫痫患者的诊断价值。方法选取2011年4月～2012年2月浙江省东阳市人民医院的73例发作间期癫痫患者、25例间歇期晕厥患者、19例间歇期偏头痛患者、31例发作间期短暂性脑缺血发作患者作为研究对象,分别在自然睡眠状态下、常规清醒状态下对上述研究对象进行EEG检查,比较其灵敏度和特异度。结果自然睡眠EEG诊断发作间期癫痫患者的灵敏度、特异度分别为75.3%、100.0%。常规清醒EEG诊断发作间期癫痫患者的灵敏度、特异度分别为31.5%、100.0%。自然睡眠EEG诊断发作间期癫痫患者的灵敏度显著高于常规清醒EEG(P<0.05),两种EEG诊断发作间期癫痫患者的特异度相比差异无统计学意义(P>0.05)。结论与常规清醒EEG相比,自然睡眠EEG诊断发作间期癫痫的灵敏度较高,有利于降低癫痫患者的漏诊率。

Objective To investigate the clinical value of natural sleep electroencephalogram（EEG） in the diagnosis of interictal epilepsy.Methods 73 cases of interictal epilepsy,25 cases of intermittent syncope,19 cases of intermittent migraine and 31 cases of interictal transient ischemic attack in Dongyang People＇s Hospital of Zhejiang Province from April 2011 to February 2012 were selected as the objects of study,and the natural sleep EEG and routine awake EEG were detected in all before-mentioned patients,the sensitivity and specificity was compared.Results The natural sleep EEG in the diagnosis of interictal epilepsy had a sensitivity of 75.3%,specificity of 100.0%,while the routine awake EEG had a sensitivity of 31.5%,specificity of 100.0%.The sensitivity of natural sleep EEG in the diagnosis of interic tal epilepsy was significantly higher than that of routine awake EEG（P〈0.05）,and there were no significant differences in the specificity between natural sleep EEG and routine awake EEG（P〈0.05）.Conclusion Compared with routine awake EEG,the natural sleep EEG in the diagnosis of interictal epilepsy has a higher sensitivity,which is beneficial to reduce the misdiagnosis rate of epilepsy.