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聚肌苷酸胞苷酸注射抑制HBV表达研究 被引量：1

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摘要 目的探讨PolyI:C注射活化机体天然免疫系统对HBV表达的影响。方法 pAAV/HBV1.2质粒高压注射小鼠构建HBV质粒慢性携带动物模型,PolyI:C注射观察其对pAAV/HBV1.2质粒表达HBV的抑制影响。结果 pAAV/HBV1.2质粒高压注射C57BL/6鼠形成HBV持续携带,PolyI:C注射能显著抑制HBV表达(P<0.05),差异有统计学意义。结论 PolyI:C注射可以促进C57BL/6鼠抑制HBV表达,这对今后的HBV免疫治疗具有一定的启示意义。
作者 殷文伟 张琼芳 童师雯
机构地区 重庆医科大学病毒性肝炎研究所
出处 《中国现代药物应用》 2013年第14期241-242,共2页 Chinese Journal of Modern Drug Application
关键词 POLYI C HBV 免疫系统
分类号 R392 [医药卫生—免疫学]
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中国现代药物应用
2013年 第14期

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