摘要
目的探讨青海省鼠疫菌株生物学特点及流行病学意义,为鼠疫防治提供科学依据。方法对2008-2012年青海省分离的鼠疫菌株进行生物学研究。结果所有被试菌株其生物型为古典型,生态型均为青藏高原型,菌株基因型为5型、8型。菌株的4个毒力因子俱全,毒力测定结果显示,MLD均在10 000个菌以下,为强毒菌株。表明这些菌株均具备青海高原喜马拉雅旱獭鼠疫自然疫源地鼠疫病原体特性。结论青海省分离的鼠疫菌株属青藏高原型,鼠疫菌的毒力强,对人类健康威胁严重。
To explore the biological characteristics and epidemiological significance of Yersinia pestis in Qinghai Province in order to provide the scientific basis for the plague prevention and control, we carried out biological research on Yersinia pestis separated there during 2008 to 2012. All the tested strains＇ hiovars was Antiqua, and ecotypes was.Qinghai-Tibetan Plateau, and the genomovars were genomovar 05 and genomovar 08. The strains were equipped with 4 virulence factors, and the virulence test results showed that MLD were below 10 000 bacteria, which meant that the strains were virulent. The above information indicated that these strains had the characteristics of the plague pathogen belonged to Marmota himalayana Plague Focus of the Qinghai Plateau. The strains separated in Qinghai Province are virulent and belongs to the Qinghai-Tibetan Plateau. Consequently, the epidemic of plague presents serious threat for humans.
出处
《中国人兽共患病学报》
CAS
CSCD
北大核心
2013年第8期826-828,共3页
Chinese Journal of Zoonoses
基金
国家自然科学基金(No.81160211)资助~~
