预制血管化骨瓣修复大面积骨缺损的研究进展

Research progress on reconstruction of large compound bone defects with prefabricated,vascularized bone flap

创伤、炎症、肿瘤、先天性畸形所引起的骨缺损修复一直是医学难题,而骨组织工程在骨缺损修复的研究中日益增多,预制骨瓣具有创伤小、血运好、抗感染能力强、可以带软组织、按照支架形状进行预制等优点,成为骨组织修复工程的研究热点。本文就预制血管化骨瓣修复大面积骨缺损的基础和临床研究做一综述。

The restoration of bone defects caused by trauma,infection,ablative surgery for tumor and congenital deformity remains a challenge for surgeons.At present,bone tissue engineering,especially prefabricated,vascularized tissue-engineered bone flap,has gone from the bench to the bedside and shown effectiveness such as less mobility of donor site,a stable blood supply to reduce the risk of infection,sufficient mature bone and soft tissues in a good threedimensional shape after prefabrication for bone reconstruction.This article presented the fundamental and clinical research of prefabricated,vascularized bone flap for restoring large compound bone defects.