信阳市新布尼亚病毒实验室检测结果

Laboratory test results of new bunyavirus in Xinyang City

目的分析信阳市新布尼亚病毒实验室检测结果,掌握发热伴血小板减少综合征流行趋势,为该地区发热伴血小板减少综合征综合防治提供参考资料。方法采集临床发热伴血小板减少综合征诊断病例血清标本579份,应用实时荧光RT-PCR技术检测新布尼亚病毒。结果 579份样本中,新布尼亚病毒核酸检测阳性295份,阳性率50.95%;其中商城县阳性率为22.45%,光山县阳性率为7.08%,占总阳性率的比例为44.07%(130/295)和13.90%(41/295)。病例发病集中在4—7月份,布尼亚病毒感染阳性率以61～70岁组最高,各年龄组差异有统计学意义(χ2=20.552,p<0.01)。结论信阳市发热伴血小板减少综合征具有一定的地域性和季节性,大年龄组高发,新布尼亚病毒为其主要病原。

[ Objective] To analyze the laboratory test results of new bunyavirus in Xinyang City, understand the epidemic tendency of fever with thrombocytopenia syndrome, and provide the reference for comprehensive prevention and control of fever with thrombo- cytopenia syndrome in Xinyang City. [ Methods ] 579 serum specimens were collected from diagnosed cases of fever with thrombocy- topenia syndrome, and new bunyavirus was detected by real time fluorescent RT-PCR. [ Results ] Among 579 serum specimens, there were 295 positive cases for nucleic acid of new bunyavirus, with the positive rate of 50.95%. The positive rate of Shangcheng County and Guangshan County was 22.45% and 7.08% respectively, which accounted for 44.07% （ 130/295 ） and 13.90% 141/295} of total positive rate. Cases were mainly occurred between April and July. The positive rate of new bunyavirus in 61-70 year-old age group was the highest, and there were significant differences between different age groups （X2 = 20.552,P 〈 0.01 }. [ Conclusion] The fever with thrombocytopenia syndrome shows a certain regional and seasonal characteristics in Xinyang City, the older age groups have higher incidence rate, and new bunyavirus is the main pathogen.