高强聚焦超声消融微米级靶体组织的理论研究

A theoretical study on the ablating micron target volume of tissue by high intensity focused ultrasound

本文对1～10MHz的高强聚焦超声能否消融微米级靶体组织进行了理论研究.用O’Nell方程求解聚焦超声声场和用Pennes方程求解生物组织的热物理学问题.研究结果表明,1～10MHz的高强聚焦超声完全可以消融微米级的靶组织体积.此理论研究结果与近期发表的最新实验研究结果一致.从而可以预期:频率为MHz级的高强聚焦超声医疗技术将可能为细胞外科开拓出崭新的临床应用前景.

Theoretical study on the possibility of ablating micron volume target tissue by 1~10 MHz high intensity focused ultrasound（HIFU）is presented in this paper.O ＇Nell equation is used to describe the focused sound field and Pennes equation is used to solve the thermal problem of the biological tissue.The theoretical study shows that the ablating tissue volume can reach as small as micron order and its size only depends on the HIFU exposure dose.This theoretical result is in agreement well with the most novel experimental result published recently.Thereby it can be predicted that the HIFU technique of MHz order frequency may open a novel clinic application prospect for the noninvasive cell surgery.