平肝熄风化痰通络颗粒治疗肝风痰瘀型眩晕临床观察

Clinical observation on “Pinggan Xifeng Huatan Tongluo Capsule”for vertigo of the liver wind and phlegm stagnation pattern

目的观察平肝熄风化痰通络颗粒治疗肝风痰瘀型眩晕的临床疗效。方法将45例肝风痰瘀型眩晕患者随机分为治疗组(30例)、对照组(15例),分别予平肝熄风化痰通络颗粒和全天麻胶囊口服,疗程均为28天。观察治疗前、治疗14天、治疗后、停药2个月后眩晕发作情况及伴随症状、平衡功能体征的变化情况,并评价临床疗效。结果①治疗结束时,治疗组、对照组综合临床疗效总有效率分别为93.3%、80.0%,组间疗效差异有统计学意义(P<0.01)。②治疗组、对照组眩晕疗效总有效率分别为96.7%、80.0%,组间疗效差异有统计学意义(P<0.01)。③治疗组、对照组治疗14天、治疗后、随访2个月眩晕发作情况总积分较本组治疗前差异均有统计学意义(P<0.05,P<0.01);组间比较,治疗14天、治疗后、随访2个月眩晕发作情况总积分差异有统计学意义(P<0.05)。④治疗组闭目难立征、步行偏斜治疗前后阳性例数比较,差异有统计学意义(P<0.05,P<0.01);对照组闭目难立征、误指试验、步行偏斜阳性例数比较,差异均无统计学意义(P>0.05);组间比较,闭目难立征、步行偏斜消失率差异有统计学意义(P<0.05)。结论平肝熄风化痰通络颗粒治疗肝风痰瘀型眩晕疗效及安全性均良好。

Objective To observe the clinical efficacy of ＂Pinggan Xifeng Huatan Tongluo Capsule＂ （ PXHT Capsule） in treating vertigo of the liver wind and phlegm stagnation pattern. Methods Fourty-five cases were randomly divided into two groups： treatment group in which 30 cases were treated by PXHT Capsule, and control group in which 15 cases were treated by ＂Quan Tianma Capsule＂, with the course of 28 days. The onset of vertigo, associated symptoms and signs of balance were observed and clinical efficacy was evaluated at different times. Results （1） The comprehensive clinical efficacy was 93.3% in the treatment group and 80.0% in the control group, with a difference between the two groups （ P 〈 0.01 ）. （2） The total effective rate of vertigo was 96.7% in the treatment group and 80.0% in the control group, with a difference between the two groups （ P 〈 0.01 ）. （3） In both of the groups, there were significant difference in scores of onset between before and after treatment. （P 〈0.05, P 〈0.01 ） ; significant difference was found between the 2 groups （P 〈 0.05 ）. （4） Significant differences were found in positive eases with Romberg＇ s sign and deflection on foot between before and after treatment. （ P 〈 0.05, P 〈 0.01 ） ; no significant differences was found in Romberg＇ s sign, past-pointing test and deflection on foot in control group （P 〉 0.05 ）. There were significant differences in Romberg＇ s sign and fade rate of deflection between the two groups （ P 〈 0.05 ）. Conclusion PXHT Capsule has positive effect on vertigo of the liver wind and phlegm stagnation pattern.