间断性站立位对抗尾部悬吊大鼠脑动脉血管反应性变化的效果

Counteracting effects of intermittent standing on responsiveness of basilar arteries from tail suspended rats

目的 探讨模拟间断性人工重力刺激对抗模拟失重下大鼠脑基底动脉血管反应性改变的效果。 方法 雄性 SD大鼠 35只 ,按体重随机分为 5组 ,即 :1同步对照组 ;2模拟失重组 (3周尾部悬吊 ) ;3模拟失重 +站立位 4h组 ;4模拟失重 +站立位 2 h组 ;5模拟失重 +站立位 1h组。每组7只。每日分别给予站立组大鼠不同持续时间 (1h,2 h或 4h)的站立位 (STD) ,测定大鼠离体基底动脉血管环对 KCl的收缩反应性。 结果 悬吊组大鼠基底动脉血管环对 KCl的最大反应较对照组显著升高 (P<0 .0 5 ) ;STD组大鼠基底动脉血管环对 KCl的最大反应较悬吊组显著减弱 (P<0 .0 5 ) ,与对照组无显著差别。 结论 每日给予尾部悬吊大鼠最少

Objective To investigate counteracting effects of intermittent standing on changes in responsiveness of basilar arteries from tail suspended rats. Methods Thirty five SD rats were divided into 5 groups: control group(CON), tail suspended 3 week group(SUS), SUS+daily standing for 4 h group(STD 4), SUS+daily standing for 2 h group(STD 2) and SUS+daily standing for 1 hour group(STD 1). After 3 wk tail suspension, responses of perfused isolated basilar arterial rings from rats of experimental groups were examined and compared with that from rats of synchronous control group. Results Maximal isometric contractile responses of isolated basilar arterial rings from SUS rats to KCl were significantly higher than those from rats of CON, STD 4, STD 2, and STD 1. The differences of responses among CON, STD 4, STD 2, and STD 1 were nonsignificant. Conclusion The results indicate that daily intermittent standing for 1 hour or more as a countermeasure to prevent the effects of simulated weightlessness on changes in responsiveness of basilar arteries from tail suspended rats is valid.