参麦注射液减轻进展期胃癌术后EAP方案化疗毒副作用疗效观察

Clinical Effects of Reducing the Chemotherapeutic Toxicity with EAP in Post-operative Chemotherapy of Advanced Gastric Cancer by Shenmai Injection

目的 :观察参麦注射液对降低进展期胃癌术后辅助化疗毒副作用的疗效。方法 :75例进展期胃癌术后患者分为两组 :单纯 EAP方案化疗组 (对照组 ) 30例及 EAP化疗并参麦液组 45例 ,化疗前及化疗后每周检查血常规、肝功能、心电图 ,观察胃肠道反应并进行 Karnofsky评分。结果 :化疗并参麦组患者外周血白细胞、血小板降低程度 ,心电图异常情况及胃肠道副作用明显低于化疗对照组 (P<0 .0 1) ,而 Karnofsky评分却明显高于对照组 (P<0 .0 5 )。结论 :参麦注射液可明显减轻和预防 EAP方案对进展期胃癌术后辅助化疗所产生的骨髓抑制、心脏毒性及消化道反应 ,从而提高患者对化疗毒副作用的耐受性及化疗期间生活质量。

Objective: To observe the clinical effects of Shenmai injection in reducing the chemotherapeutic side effects with EAP in post operative adjuvant chemotherapy of advanced gastric cancers.Methods:75 post operative cases of advanced gastric cancers were divided randomly into 2 groups, group of EAP chemotherapy (control group), 30 cases; and group of EAP chemotherapy combined with Shenmai injection (group of Shenmai), 45 cases. The blood routine, liver function and electrocardiogram were examined, the gastrointestinal side effects and Karnofsky index were assessed everyweek pre and post chemotherapy.Results: The reduced degrees of the white blood cells and the platelets, the abnormality of EKG and the gastrointestinal side effects in patients in Shenmai group were obviously lower than those of control group (P<0.01), and the Karnofsky scores in Shenmai group were much higher than that of the control group (P<0.05). Conclusion: The Shenmai injection could markedly prevent and relieve the cardiotoxin, marrow inhibition and gastrointestinal side effects produced by the post operative adjuvant chemotherapy with EAP in advanced gastric cancers, therefore, may raise the endurance of patients to side effects of chemotherapy and the life qualities during chemotherapy.