脑梗死患者可溶性E-和P-选择素水平变化及意义

The significance of the changes of soluble E-and P-selectins in patients with acute cerebral infarction

目的:探讨E-和P-选择素与脑梗死的关系。方法应用ELISA方法测定30例脑梗死患者,25例脑出血患者及28例正常人的sE-和sP-选择素血清水平。结果 急性期脑便死患者sE-和sP-选择素血清水平明显高于脑出血患者及正常人。急性期脑梗死患者sE-和sP-选择素水平分别与WBC、N％、IL-6水平呈正相关关系,sP-选择素水平还与TNF水平呈正相关关系。结论sE-和sP-选择素血清水平增高反映脑便死急性期E-和P-选择素可能在TNF和IL-6的刺激下,参与脑梗死损伤过程。

Objective To determine the roles of E - and P - selectins in the pathogenesis of cerebral infarction. Methods: The serum concentrations of sE -and sP -selectns were measured with ELISA in 30 cerebral infarction. 25cerebral haemorrhage and 28 healthy control subjects. Result: The serum levels of sE-and sP-selectins in acute stage of cerebral infarction group were significantly higher than those in cerebral haemorrhage and those in healthy control group. In sE-selectin, as well as the level of sP-selectin, was observed in positive correlation with the WBC, N%, or the level of IL -6 respectively. The level of sP-selectin was also positively correlated with the level of TNF. Conclusions: The increased levels of sE-and sP- selectins reflected these two selectins might be enhanced the endotheliocyte - leukocyte adhesion, under the stimulations of TNF and IL - 6, so as to be involved in the cerebral injury after acute cerebral infarction.