乳腺肿物^(99m)Tc-MIBI显像、钼靶X线诊断对照分析

Control Study of ^(99m)Tc-MIBI imaging and mammography in the diagnosis of breast tumor

目的 :分析比较99mTc -MIBI(甲氧基异丁基异腈)乳腺显像与钼靶X线摄影法对乳腺肿块的临床诊断价值。方法 :40例单侧乳腺肿块患者 ,包括良性病变29例 ,恶性病变11例 ,在1周内同时接受99mTc -MIBI乳腺显像和钼靶X线摄影检查。钼靶X线片结合放大镜观察钙化点的情况分析 ,99mTc -MIBI显像取感兴趣区(ROI) ,求出肿块与正常组织中放射性比值(T/NT)。结果 :99mTc-MIBI显像T/NT放射性比值 ,恶性为1 98±0 22(n=12) ;良性为1 16±0 10(n=28) ;两者有显著性差异(P<0 01)。99mTc-MIBI显像与钼靶X线摄影法诊断乳腺癌的灵敏度和特异性分别为83 3%、92 8%和90 9 %、24 1%。结论 :钼靶X线摄影发现乳腺恶性病变敏感性高而特异性低 ;99mTc-MIBI显像对乳腺肿块诊断特异性和准确性明显优于钼靶X线摄影 ,两种影像方法各有所长 ,如果结合应用 。

Objective:To evaluate the value of 99mTc-MIBI imaging and mammography in the diagnosis of breast tumor.Methods:99m Tc-MIBI imaging and mammography were performed within one week for 40 patients with palpable breast tumor(benign lesion 29,malignant lesion 11).The mammograms were read with calcifications observed under a magnifying glass.In 99mTc-MIBI imaging,region of interesting(ROI) was drawn and the ratio of radioactivity in tumor and nontumor tissue was calculated.Results:The ratio of T/NT was 1.98±0.22(n=12) in malignant tumor and 1.16±0.10(n=28) in benign lesion.There was significant difference by statistics (P<0.01).The sensitivity and specificity of 99mTc-MIBI imaging and mammography in the diagnosis of breast cancer were 83.3%,92.8%and 90.9%,24.1%,respectively.Conclusion:The mammography has higher sensitivity but lower specificity in the diagnosis of malignant tumor.99mTc-MIBI imaging has higher specificity.Both have their own advantages in the diagnosis of breast tumor.The accuracy of diagnosis will be improved with both methods.