灯盏细辛治疗一氧化碳中毒后迟发性脑病疗效研究

Analysis of erigeron's therapeutic effect of the delayed encephalopathy caused by carbon monoxide poisoning

目的观察灯盏细辛注射液对一氧化碳中毒后迟发性脑病(delayed encephalopathy after acute carbon monoxide poisoning,DEACMP)的治疗效果观察。方法 76例DEACMP患者随机分为对照组34例,常规综合治疗,高压氧加降颅压、营养脑细胞、激素及对症治疗;治疗组32例在对照组治疗方案基础上加用灯盏细辛注射液40ml/d静脉滴注。入院时及20d后应用长谷川痴呆量表(HDS)和日常生活能力(ADL)进行评定,并观察2组临床治疗效果。结果治疗组总有效率为93.75%高于对照组的76.47%,差异有统计学意义(P<0.05);且2组治疗后神经功能评分差异有统计学意义(P<0.05)。结论灯盏细辛注射液是治疗CO中毒迟发性脑病的有效药物,且不良反应少。

Objective To observe the therapeutic effect of erigeron injection on the delayed encephalopathy after acute carbon monoxide poisoning （DEACMP）.Methods 76 cases of DEACMP patients were randomly divided into two groups.Control group （34 cases）is treated by conventional therapy,hyperbaric oxygen plus reducing the intracranial pressure, nourishing brain cells,and hormones and symptomatic treatment.Based on the control group,40ml / d erigeron injection of intravenous drips is added to the treatment group （32 cases）.When the patients were admitted and three weeks later,they were evaluated by Hasegawa Dementia Scale （HDS）and activities of daily living （ADL）respectively,divided into groups of being cured after treatment,having obvious effects,being improved,and being invalid after treatment.Results The total effective rate of the treatment group was 93.75% ,which was higher than 76.74% of the control group,the difference was statistically significant （P0.05）.The difference of neurological function score was statistically significant in 2 groups after treatment （P 0.05）.Conclusion Erigeron injection is an effective drug for treatment of DEACMP,with fewer adverse reactions.