芬太尼与曲马朵用于腹腔镜胆囊切除术后镇痛效果比较

Comparison postoperative analgesia between fentanyl and tramadol in laparoscopic cholecystectomy

目的 比较芬太尼与曲马朵用于腹腔镜胆囊切除术后镇痛的临床疗效.方法 80例腹腔镜胆囊切除术患者按照数字表法随机分为芬太尼组（F组）及曲马朵组（Q组）各40例,观察比较两组术后0.5、1、2、4、8、12 h的VAS评分及不良反应发生率、患者满意度.结果 F组在给药后0.5、1、2h时VAS 0～3分患者所占比例明显高于Q组（x2 =5.56、5.50、4.47,均P＜0.05）,F组在给药后4、8h时VAS 0～3分患者所占比例低于Q组（x2 =6.23、7.22,均P＜0.05）,而两组在给药12 h时VAS评分差异无统计学意义（P＞0.05）.F组不良反应发生率高于Q组、患者满意度高于Q组,两组差异均有统计学意义（x2=12.12、4.44,均P＜0.05）.结论 静脉注射芬太尼在腹腔镜胆囊切除术后总体镇痛效果优于曲马朵,患者满意度高.

Objective To observe the effects of intravenous injection of fentanyl and tramadol on postopera- tive analgesia in laparoscopic cholecystectomy of clinical efficacy. Methods 80 cases treated with laparoscopic chole- cystectomy were randomly divided into the fentanyl group （group F） and tramadol group （group Q ）. VAS score, ad- verse reaction incidence and patient satisfaction, were observed after the administration of 0. 5, 1,2,4, 8, 12h. Results In group F after administration of 0.5,1,2h, VAS score was better than that of group Q ; group F after ad- ministration of the drug 4,8 h VAS score was inferior to group Q ; two groups of patients in postoperative 12h VAS scores showed no significant difference in group F;the overall incidence of adverse reactions was higher than that of group Q,patients＇ satisfaction was higher than that of group Q. Conclusion Intravenous fentanyl in laparoscopic cholecystectomy operation postoperative overall are superior to the analgesic effect of tramadol, with high patient＇s sat- isfaction.