甲泼尼龙冲击治疗急性期多发性硬化症疗效观察

The clinical effects of methylprednisolone pulse therapy on the acute treatment of multiple sclerosis

目的 观察甲泼尼龙冲击治疗急性期多发性硬化症的临床效果.方法 选取46例急性期多发性硬化患者,按照数字表法随机分为观察组和对照组各23例,观察组给予甲泼尼龙治疗,对照组给予地塞米松治疗.观察比较两组临床疗效和并发症发生情况.结果 观察组显效14例,有效5例,无效4例,总有效率为82.6％；对照组显效10例,有效4例,无效9例,总有效率60.9％；两组总有效率差异有统计学意义（X2=5.236,P＜0.05）.治疗后,两组Kurtzke神经功能量表评分均较治疗前有所下降,观察组显著低于对照组（t =3.135,P＜0.05）.结论 对急性期多发性硬化患者使用甲泼尼龙冲击治疗,可以减少并发症的发生,减少患者神经系统损害,改善患者生存质量.

Objective To investigate the value of methylprednisolone pulse therapy on the acute treatment of multiple sclerosis. Methods 46 cases of the acute phase of patients with multiple sclerosis treatment in the hospital＇ s department of neurology were chosen, who were divided in accordance with the principle of randomized controlled study group and the control group, each group of 23 patients. The study group was given methylprednisolone in the treatment and control group were given dexamethasone treatment. The clinical efficacy and complications of the treat- ment of patients were compared. Results The study group markedly in 14 cases, effective 54 cases, the total effective rate was 82.6% ;the control group, 10 cases markedly effective in 4 cases ,9 cases ineffective, the total effective rate was 60.9% ; compared the two sets of data decline before treatment, there was a statistically significant difference （ X2 = 5. 236, P 〈 0.05 ）. After the treatment, the two groups of patients with EDSS scores compared with EDSS scores of the study group was significantly lower than that of the control group, the difference was statistically significant（ t = 3. 135 ,P 〈 0.05）. Conclusion In acute phase of patients with multiple sclerosis, methylprednisolone pulse therapy can reduce the incidence of complications, and reduce the patient＇s nervous system damage, which can improve the quality of life in patients.