氟康唑与伏立康唑治疗念珠菌肺炎的疗效比较

Contrast of therapeutic effects between voriconazole and fluconazole in treatment of pulmonary candidiasis

目的 比较伏立康唑与氟康唑治疗肺部念珠菌感染的疗效与安全性.方法 79例肺念珠菌感染患者按照住院号顺序分为伏立康唑组与氟康唑组,观察患者症状和体征变化,评价感染治愈率及治疗安全性.结果 伏立康唑组总体有效率为93.1％,明显高于氟康唑组的65.9％（x2=7.51,P＜0.01）,痊愈率分别为65.1％和36.1％,差异均有统计学意义（x2 =6.60,P＜0.05）.伏立康唑组不良反应发生率为14.0％,氟康唑组不良反应发生率为16.7％,两组差异无统计学意义（P＞0.05）.结论 伏立康唑治疗肺部念珠菌感染效果优于氟康唑,两者安全性均较高.

Objective To observe the efficacy and safety of voriconazole in the treatment for the patients in- fectedwith Candida species. Methods 79 patients were randomly divided into vorioonazole treatment group and flu- conazole treatment group. And they were enrolled and were administered voriconazole. Results The total effective rate of experimental group was 93.1% ,and that of control group was 65.9% and the difference was significant（ P 〈 0.05 ）. the risk factors of the two groups showed no obvious difference, the adverse reaction incidence rate in voricon- azole treatment group was 16.7% ,And that in flueonazole treatment group was 14.0% ,there was no significant differ- ence between the two groups. Conclusion The application of voriconazole can receive better effect than that of flu- conazole. And it has good clinical safety, and voriconazole is worthy of application in clinic for Candida infection.