贝那普利对原发性高血压患者血浆炎性细胞因子水平的影响

Effects of benazepril on inflammatory cytokines in patients with primary hypertension

目的 探讨贝那普利对原发性高血压患者血浆炎性细胞因子白细胞介素（IL）-4、IL-8、IL-10水平的影响.方法 选择轻中度原发性高血压患者72例,采用随机数字表将患者分为贝那普利组（37例）与对照组（35例）.对照组患者予以菲洛地平缓释片5 ag,1次/d.贝那普利组予以贝那普利片10 mg,1次/d,两组疗程均为8周.观察两组患者治疗前后血压和心率的变化,并进行血浆IL-4、IL-8、IL-10水平的测定及不良反应的观察.结果 治疗8周后,两组患者的血压均较前明显下降（t =2.87、2.43、2.31、2.23,P＜0.05或P＜0.01）,且贝那普利组下降的幅度较对照组更明显（t=2.21、2.13,均P＜0.05）；同时两组患者血浆IL-4和IL-8水平均较前明显下降、血浆IL-10水平均较前明显上升（t=2.99、2.87、3.21、2.13、2.19、2.23,均P＜0.05或P＜0.01）,且贝那普利组下降或上升的幅度较对照组更明显（t=2.21、2.13、2.34,均P＜0.05）.结论 贝那普利治疗原发性高血压具有良好的降压作用,安全性较好,能明显降低患者血浆IL-4和IL-8水平,提高IL-10水平,具有抑制血管壁炎性反应的作用.

Objective To investigate the effects of Benazepril on inflammatory cytokines in patients with primary hypertension and its efficacy analysis.Methods 72 patients with mild to moderate primary hypertension were randomly divided into benazepril group（37 cases）and control group（35 cases）.The control group patients were given felodipine sustained release tablets Stag,1 times daily.Benazepril group were given benazepril tablets 10mg,1 times daily.Both groups were treated for 8 weeks.Changes in blood pressure and heart rate,plasma inflammatory cytokine levels and the adverse reactions were observed.Results After 8 weeks of treatment,the patients＇ blood pressures were significantly decreased （t =2.87,2.43,2.31,2.23,P 〈 0.05 or P 〈 0.01） than before in both groups.And the decrease in the benazepril group was more obvious than that in the control group （t =2.21,2.13,all P 〈 0.05）,while the patients＇ heart rates in the two groups showed no significant change （P 〉 0.05） ; Patients＇ plasma IL-4 and IL-8 levels decreased significantly,plasma IL-10 levels increased significantly （t =2.99,2.87,3.21,2.13,2.19,2.23,all P〈0.05 or P〈0.01）,and the magnitude of decrease or increase in the benazepril group were more obvious compared with the control group （t =2.21,2.13,2.34,all P 〈 0.05）.Conclusion Benazepril in the treatment of primary hypertension has good antihypertensive effect and security which can significantly reduce the plasma levels of proinflammatory cytokines IL-4 and IL-8 levels,improve the anti-inflammatory cytokine IL-10 levels,and has the role of suppressing the inflammatory response of the vessel wall.