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Palladium-Catalyzed Cross-Coupling of Fluorinated Vinyl Chlorides with Terminal Alkynes: A General Protocol to Fluorinated Enynes

Palladium-Catalyzed Cross-Coupling of Fluorinated Vinyl Chlorides with Terminal Alkynes: A General Protocol to Fluorinated Enynes
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摘要 An efficient and cost-effective method for the preparation of fluorinated conjugated enynes was described, tile method was compatible with a variety of functional groups such as chloride, amine, cyano and ester group. The method could also be extended to the coupling of (R,Z)-3-(2-chloro-1,2-difluorovinyl)-4-alkyloxazolidin-2-one (3) with moderate yields. An efficient and cost-effective method for the preparation of fluorinated conjugated enynes was described, tile method was compatible with a variety of functional groups such as chloride, amine, cyano and ester group. The method could also be extended to the coupling of (R,Z)-3-(2-chloro-1,2-difluorovinyl)-4-alkyloxazolidin-2-one (3) with moderate yields.
出处 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2013年第7期901-907,共7页 中国化学(英文版)
基金 Acknowledgement The authors gratefully acknowledge the financial support from National Basic Research Program of China (Nos. 2012CB821600, 2010CB126103), the Key Program of Natural Science Foundation of China (No.21032006), National Natural Science Foundation of China (Nos. 21172245, 21172244, B020304), Agroscientific Research in the Public Interest (No. 201103007), the National Key Technologies R&D Program (No. 2011BAE06B05), Shanghai Scientific Research Program (No. 10XD1405200), and SIOC.
关键词 FLUORINE ENYNE PALLADIUM CHLOROTRIFLUOROETHYLENE fluorine, enyne, palladium, chlorotrifluoroethylene
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