IL13基因C-1112T多态性与肿瘤易感性分析研究

The correlation between ILl3 C-1112T polymorphism and cancer risk： a meta-analysis

目的白介素-13（IL-13）是一类免疫调节的细胞因子，其通过影响肿瘤的免疫监视从而在肿瘤形成过程中起重要作用。本文采用Meta分析研究IL-13C-1112T基因多态性位点在肿瘤发生风险中的影响。方法在纳入的16项研究中，总共有4552名肿瘤病例和7182名对照组个体，从这些研究中搜集数据并且采用95％置信区间的OR值来评估基因多态性与肿瘤易感之间的相关性。结果本研究表明，IL13基因C-1112T多态性与整个肿瘤易感性无明显相关。然而在分层分析中发现IL13 C-1112T多态性可以降低神经胶质瘤的发病风险（TC vs．CC：固定效应模型OR=0．718，95％口为0．55-0．93；TC＋TT vs．CC：固定效应模型OR=0．76，95％CI为0．62-0．89）。结论IL13基因C-1112T多态性可能与恶性肿瘤特别是神经胶质瘤易感性存在一定的相关性。

Objective To study the correlation between ILl 3 C-1112T polymorphism and cancer risk. Methods PubMed database was utilized to search articles related to correlation between ILl3 C-1112T polymorphism and cancer risk. All the statistical analysis was performed by STATA software. Results No association was observed in the overall analysis. However, in the stratified analysis, we found ILl3 C-1112T polymorphism was significantly associated with decreased risk of glioma（TC vs. CC： 0//=0.72, 95%CI=0.55- 0.93; TC ＋ TT vs. CC： OR=0.76, 95%CI=0.62-0.89）. Conclusion ILl3 C-1112T polymorphism may be correlated with glioma risk.