辛伐他汀联合低分子肝素在心绞痛中的临床应用

The clinical application of simvastatin combined with low molecular heparin in angina pectorls

目的探讨辛伐他汀联合低分子肝素对心绞痛的临床治疗价值。方法将我院2010年3月到2011年9月间收治的172例心绞痛患者随机均分为两组，对照组在常规治疗的基础上给予辛伐他汀，联合组给予低分子肝素和辛伐他汀联合用药治疗，用药一个疗程后对比两组治疗有效率及不良反应发生率情况。结果一个疗程后，联合组患者治疗总有效率为95．35％，显著高于对照组的74．41％，联合组不良反应发生率（8．14％）显著低于对照组（22．09％），两组比较差异具有统计学意义（P〈0．01）。结论低分子肝素联合辛伐他汀治疗心绞痛疗效确切，值得临床推广应用。

Objective To study the clinical value of simvastatin combined with low molecular heparin in the treatment of angina pectoris. Methods From March 2010 to September 2011, 172 patients with angina pectoris in our hospital were randomly and equally divided into two groups. Control group was treatedwith simvastatin on the basis of conventional treatment, while combined treatment group was treated with low molecular heparin combined with simvastatin. After a course of treatment, compared treatment effect and incidences of adverse reactions of two groups. Results After a course of treatment, the totM effective rate of combined treatment group was significantly higher than that of control group（95.35 % vs 74.41%）, the incidence of adverse reactions was significantly lower than that of control group （ 8.14% vs 22.09% ） , the differences were statistically significant（P 〈 0.01）. Conclusion Low molecular heparin combined with simvastatin in the treatment of angina pectoris is effective, worthy of clinical application.