探讨肝素在治疗新生儿弥漫性血管内凝血中的剂量、给药方法及时机

Dosage and medication method and time of heparin for neonatal disseminated intravascular coagulation

目的探讨肝素在治疗新生儿弥漫性血管内凝血（D1C）中的剂量、给药方法及时机。方法选择2010年10月至2013年4月我院发生DIC的40例新生儿为研究对象。将其随机分为实验组和对照组，各20例。所有患儿均行综合治疗，实验组早期静脉注射微剂量肝素治疗，对照组静脉注射常规剂量肝素治疗。观察比较两组患儿住院天数、住院费用、治愈率、病死率及不良反应发生情况。结果实验组住院天数、住院费用、治愈率、病死率与对照组比较，差异均具有统计学意义（P〈0．05）。所有存活患儿均无出血倾向。结论早期静脉注射小剂量肝素治疗各期新生儿DIC，安全有效，不良反应少，值得临床推广使用。

Objective To explore the dosage and medication method and time of heparin for neonatal disseminated intravascular coagulation （DIC）. Methods 40 newborns with DIC chosen from our hospital from October 2010 to April 2013 were randomly divided into an experimental group and a control group, 20 for each group. All patients underwent comprehensive treatment. The experimental group were intravenously injected a micro-dose of heparin, while the control group intravenously took a conventional dose of heparin. The cure rates, mortalities, hospitalization cost, length of hospital stay, and adverse occurrences of both groups were observed. Results There were statistical differences in cure rate, mortality, length of hospital stay, hospitalization cost,and mortality between the experimental group and the control group （P 〈 0.05）.Conclusions Intravenous injection of a small dose of heparin for newborn DIC is safe and effective and has fewer adverse reactions, and is worth being clinically generalized.