复发性外阴阴道假丝酵母菌病治疗方案及疗程的研究分析

Analysis and research on treatment and course for recurrent vulvovaginal candidiasis

目的探讨研究复发性外阴阴道假丝酵母菌病治疗方案及疗程。方法将我院从2011年9月至2012年6月收治的300例复发性外阴阴道假丝酵母菌病患者按照随机数表法均分为3组，A组100例采用硝酸咪康唑栓200mg／d治疗7～10d，B组100例采用硝酸咪康唑栓400mg／d治疗4—7d，C组100例在B组基础上在第4日、第7日和第10日口服氟康唑150mg。分别统计记录治疗后2d、7d、14d的真菌转阴率和用药依从性，并根据临床症状评判治疗疗效；随访跟踪6个月，统计复发率。结果三组患者在2d、7d、14d的真菌转阴率和复发率上组间比较差异无统计学意义（P〉0．05）；在用药依从性和症状消失时间上，B、C两组优于A组，C组治疗有效率为97％，高于A组、B组，组间比较差异有统计学意义（P〈0．05）。结论口服用药联合局部用药能有效提高复发性外阴阴道假丝酵母菌病治疗疗效，短期安全高浓度用药能提高用药依从性。

Objective To investigate the treatment and course for recurrent vulvovaginal candidiasis. Methods 300 patients were divided into 3 groups according to the random numbex table： group A of 100 patients with mieonazole nitrate suppository 200mg/d treatment for 7-10 d, 100 cases of group B miconazole nitrate suppository 400 mg/d treatment for 4-7 days, the group C, 100 cases on the basis of group B in the 4th, the 7th and the 10th day of oral fluconazole 150 rag. We collected the data of treatment efficience. Results The 2 d, 7 d, 14 d of funga｜ negative rate and recurrence rate in the patients of three groups had no statistical significant difference （P〉0.05）; for the medication compliance and symptoms, group B and C were better than those in group A, group C treatment response rate was 97%, higher than that of group A and group B, the difference between the groups was statistically significant （P〈0.05）. Conclusion The combined topical oral medication can effectively improve the recurrent vulvovaginal candidiasis therapy, short term high save concentrations of medication can improve medication compliance.