摘要
目的探讨复方异丙托溴铵溶液联合布地奈德混悬液雾化吸入治疗D组慢性阻塞性肺疾病急性加重期(AE-COPD)患者的临床疗效。方法 60例D组AECOPD患者随机分为治疗组和对照组,每组30例。2组患者均采用抗感染、平喘、吸氧、祛痰等常规治疗,治疗组雾化吸入复方异丙托溴铵溶液联合布地奈德混悬液,对照组不给予雾化治疗。测定并比较2组患者治疗前及治疗7 d后呼吸困难评分、6 min步行距离、动脉血气等指标。结果 2组患者治疗前呼吸困难评分、6 min步行距离及动脉血pH值、动脉血氧分压Pa(O2)、动脉血二氧化碳分压Pa(CO2)等指标的变化差异均无统计学意义(P>0.05);治疗7d后2组患者呼吸困难评分、6min步行距离及pH值、Pa(O2)、Pa(CO2)与同组治疗前比较,差异均有统计学意义(P<0.05);治疗7 d后治疗组与对照组比较,呼吸困难评分、6 min步行距离及pH值、Pa(O2)、Pa(CO2)的变化差异均有统计学意义(P<0.05)。结论复方异丙托溴铵溶液联合布地奈德混悬液雾化吸入治疗D组AECOPD患者,疗效确切,值得临床推广。
Objective To investigate the clinical effect of inhaled compound ipratropium bromide solution combined with budesonide suspension in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD) of group D.Methods Sixty patients with AECOPD of group D were randomly divided into treatment group and control group with 30 in each group.The treatment group received inhaled compound ipratropium bromide solution combined with budesonide suspension plus regular anti-infection,anti-wheezing,oxygen and sputum suction while the control group just received the regular treatment.The dyspnea score,6 minute walk distance test(6MWD) and artery blood gas analysis in two groups were observed before and 7 days after the treatment respectively.Results There were no statistical differences in the dyspnea score,6 MWD,pH value,Pa(O2) and Pa(CO2) of the two groups before the treatment(all P0.05).There were statistical differences in the dyspnea score,6MWD,pH value,Pa(O2) and Pa(CO2) of the two groups 7 days after the treatment compared with those before the treatment(all P0.05).There were statistical differences in the dyspnea score,6MWD,pH value,Pa(O2) and Pa(CO2) of the treatment group compared with the control group 7 days after the treatment(all P0.05).Conclusion The inhaled compound ipratropium bromide solution combined with budesonide suspension is efficient in the treatment of patients with AECOPD of group D.
出处
《实用临床医药杂志》
CAS
2013年第9期98-100,共3页
Journal of Clinical Medicine in Practice
关键词
复方异丙托溴铵溶液
布地奈德混悬液
慢性阻塞性肺疾病急性加重期
雾化吸入
compound ipratropium bromide solution
budesonide suspension
acute exacerbation of chronic obstructive pulmonary disease(AECOPD)
aerosol inhalation