5-脂氧合酶在三阴性乳腺癌中的表达及其临床意义

Clinical significance of the 5-lipoxygenase expression in triple-negative breast cancer

目的探讨5-脂氧合酶(5-LOX)在三阴性乳腺癌(TNBC)中的表达及其临床意义。方法免疫组化法检测178例TNBC组织中5-LOX的表达情况,分析其与临床病理特征的相关性,并通过随访,分析不同表达组的生存情况。结果 TNBC组织中5-LOX阳性表达率70.22%(125/178),其阳性表达与组织学分级、淋巴结转移呈正相关(P<0.05)。随访显示5-LOX阴性表达组5年无复发生存率和总生存率明显高于阳性表达组(43%∶13%,96%∶91%)。结论 5-LOX的阳性表达与TNBC的不良预后相关,可能成为TNBC治疗的新靶点。

Objective To investigate the expression and the clinical significance of the 5-lipoxygenase in triple-negative breast cancer.Methods The immunohistochemical staining was adopted to detect the expression of 5-lipoxygenase in 178 cases of triple-negative breast cancer.The relation of 5-lipoxygenase expression with the clinicopathological characreristics was analyzed statistically.All the patients were followed-up.Results The positive rate of 5-lipoxygenase expression was 125/178 in triple negative breast cancer.5-lipoxygenase was significantly correlated with histological grade and lymph node metastasis（P0.05）.The follow-up showed that the 5-year disease-free survival and overall survival of the patients with the positive 5-lipoxygenase expression were lower than those with negative 5-lipoxygenase expression（43% vs 13%,96% vs 91%）.Conclusion The triple-negative breast cancer patients with positive 5-lipoxygenase expression have poor prognosis.5-lipoxygenase may serve as a therapeutic target for the triple negative breast cancer.