局部注射甲氨蝶呤治疗血清人绒毛膜促性腺激素较高的输卵管妊娠患者的临床研究效果评价

Clinical research on local injection of methotrexate in tubal pregnancy patients with higher blood human chorionic gonadotropin

目的探讨局部注射甲氨蝶呤对血清人绒毛膜促性腺激素(HCG)较高的输卵管妊娠患者的临床效果。方法将128例行输卵管妊娠术的患者随机分为治疗组64例和对照组64例,对照组采用腹腔镜手术治疗,治疗组采用腹腔镜手术加甲氨蝶呤局部注射治疗。比较2组患者治疗后血HCG降低例数及血HCG降低所需的天数。结果治疗组患者在术后第1、3、7、10天时血HCG降低例数显著多于对照组,且治疗组血HCG降低>60%、>80%以及HCG转阴所需天数均显著短于对照组。结论局部注射甲氨蝶呤能显著降低输卵管妊娠患者的血HCG,促进血HCG快速转阴,且毒副作用小,值得在临床上推广应用。

Objective To study the clinical effect of local injection of methotrexate on tubal pregnancy patients with higher blood human chorionic gonadotropin（HCG）.Methods One hundred and twenty-eight patients receiving tubal pregnancy operation were randomly divided into treatment group（n=64） and control group（n=64）.The control group received laparoscope surgery,while the treatment group with laparoscope surgery combined with local injection of methotrexate.The cases with decreased blood HCG and days of blood HCG to decrease were compared in the two groups.Results The cases with decreased blood HCG in the treatment group were markedly more than those the in control group 1,3,7 and 10 days after operation.The days of HCG decrease 60%,80% and HCG transforming into negative in the treatment group were all shorter than those in the control group.Conclusion Local injection of methotrexate can effectively reduce blood HCG in tubal pregnancy patients,promote it to transform into negative quickly,and has mild adverse reactions,so it deserves to be popularized and applied in clinical practice.