期刊文献+

新辅助放化疗在低位直肠癌保肛术中的应用 被引量:8

下载PDF
导出
摘要 目前,全直肠系膜切除(TME)已经成为直肠癌手术治疗的金标准,但由于盆腔的特殊解剖结构,以及大多数患者发现时已属中晚期病变,彻底清除病灶及清扫病灶周围淋巴难以达到理想的效果,且临床上高位直肠癌和中低位直肠癌术后局部复发率差异显著[1]。随着人们生活水平的提高,保肛手术显得尤为重要,对于低位直肠癌需加强以局部治疗为主的综合治疗,而术前新辅助治疗对于术后的辅助治疗具有明显优势。本研究对50例低位直肠癌患者应用术前新辅助放化疗,取得了良好效果,现报告如下。
出处 《实用临床医药杂志》 CAS 2013年第11期147-148,共2页 Journal of Clinical Medicine in Practice
基金 中国高校医学期刊临床专项资金(11320091)
  • 相关文献

参考文献12

  • 1梁毅超,卿三华,丁卫星,陈平雁,黄玉宝,于海涛.全直肠系膜切除术对比传统手术治疗直肠癌的荟萃分析[J].中华胃肠外科杂志,2007,10(1):43-48. 被引量:37
  • 2Pahlman L.Optimal timing of surgery after preoperativechemoradiotherapy for rectal cancer[J].J Ann Surg,2008,248(2):243.
  • 3Penopoulos V,Handolias M,Avgerinos A,et al.A shortcourse of preoperative radiotherapy improves prognosis of op-erable rectal carcinoma:a case control study[J].Hepatogas-troenterology,2008,55(85):1280.
  • 4Wolpin B M,Meyerhardt J A,Mamon H J,et al.Adjuvanttreatment of colorectal cancer[J].CA Cancer J Clin,2007,57(3):168.
  • 5Minsky B D.Adjuvant therapy of rectal cancer[J].SeminOncol,1999,26(5):540.
  • 6Osti M F,Valeriani M,Masoni L,et al.Neoadjuvantchemoradiaion for locally advanced carcinoma of the rectum[J].Tumori,2004,90(3):303.
  • 7Hosein P J,Rocha-Lima C M.Role of combined-modal-itytherapy in the management of locally advanced rectal cancer[J].Clin Colorectal Cancer,2008,7(6):369.
  • 8Korkrila E,Jaakkola P M,Syrjanen k,et al.Preoperativeradiaotherapy down regulates the nuclear expression of hy-poxia inducible factor alpha in rectal cancer[J].Scand J Gas-troenterol,2010,45(3):340.
  • 9薛小军,陈少全,涂小煌,宋京翔.直肠癌新辅助治疗联合保肛手术34例分析[J].中国普外基础与临床杂志,2010,17(8):824-827. 被引量:9
  • 10Shirasaka T,Shimamoto Y,Ohshimo H,et al.Developmentof a novel form of an oral 5-fluomuracil derivative(S-1)d-irected to the potentiation of the tumor selective cytotoxicity of5-fluorouracil by two biochemical modulators[J].AnticancerDrugs,1996,7(5):548.

二级参考文献56

共引文献43

同被引文献84

  • 1陈纲,李世拥,崔伟,陈光.低位直肠癌保肛手术后局部复发的因素分析[J].临床军医杂志,2010,38(4):503-505. 被引量:6
  • 2Juan Lucas Poggio. Premalignant Lesions of the Anal Canal and Squa- mous Cell Carcinoma of the Anal Canal[ J ]. Clinics in colon and rectal surgery ,2011,24 ( 3 ) : 177 - 192.
  • 3I Giani,M Mistrangelo, C Fucini, et al. The treatment of squamous a- nal carcinoma:guidelines of the Italian Society of Colo-Rectal Surgery [ J]. Techniques in coloproctology, 2013,17 (2) : 171 - 179.
  • 4Kreuter A, Brockmeyer NH,Wieland U et al. Anal intraepithelial neo- plasia and anal carcinoma:an increasing problem in HIV patients [ J]. Der Hautarzt ; Zeitscbrift frier Dermatologie, Venerologle, und ver- wandte Gebiete ,2010,61 ( 1 ) :21 - 26.
  • 5Trotti A,Coleves AD,Setser A,et al.CTCAE v 3.0:development of a comprehensive grading system for the adverse effects of cancer treatment[J].Semin Raidat Oncol,2003,13(3):176-181.
  • 6Daiko H,Hayashi R,Saikawa M,et al.Surgical management of carcinoma of the cervical esophagus[J].J Surgical Oncol,2007,96:166-172.
  • 7Budach V,Stuschke M,Budach W,et al.Hyperfractionated accelerated chemoradiation with concurrent fluorouracil-mitomycin is more effective than dose-escalated hyperfractionated accelerated radiation therapy alone in locally advanced head and neck cancer:final results of the radiotherapy cooperative clinical trials group of the German Cancer Society 95-06 Prospective Randomized Trial[J].J Clinical Oncology,2005,23(6):1125-1135.
  • 8Jeffrey ST,Kathryn M,Nirmal G,et al.Chemoradiotherapy for locally advanced head and neck cancer:10-year follow-up of the UK Head and Neck(UKHAN1)tri-al[J].Lancet Oncol,2010,11(1):66-74.
  • 9Offermans NS, Vermeulen R, Burdorf A, et al. Occupational asbestos exposure and risk of esophageal, gastric and color- ectal cancer in the prospective Netherlands Cohort Study [ J 1. International journal of cancer. Journal international du cancer,2014,135 (8) : 1970-1977.
  • 10Madbouly KM, Hussein AM. Changing operative strategy fr- om abdominoperineal resection to sphincter preservation in T3 low rectal cancer after downstaging by neoadjuvant che- moradiation : A preliminary report [ J 3. World J Surg,2015,6 (20) :122-125.

引证文献8

二级引证文献40

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部