老年高血压脑梗死患者高同型半胱氨酸血症与动脉僵硬度的相关性研究

Correlation analysis of homocysteine and pulse wave velocity in elderly patients with hypertensive cerebral infarction

目的对老年高血压脑梗死患者血浆同型半胱氨酸(Hcy)水平与动脉脉搏波传播速度(PWV)的相关性进行分析,探讨血浆Hcy水平与动脉僵硬度之间的关系。方法将老年高血压脑梗死患者分为Hcy≥15μmol/L组和Hcy<15μmol/L组;同时以1 400 cm/s作为临界值,分为正常组(BaPWV<1 400 cm/s)和非正常组(BaPWV≥1 400 cm/s),测定BMI、FPG、TG、LDLC、HDLC、TC、SBP、PP、PPI、BaPWV、Hcy等指标。结果 Hcy≥15μmol/L组SBP、PP、PPI、BaPWV均明显高于Hcy<15μmol/L组(P<0.05);BaPWV非正常组SBP、PP、PPI、BaPWV明显高于正常组(P<0.05);Hcy与SBP、PP、PPI、BaPWV正相关;BaPWV与SBP、PP、PPI、Hcy正相关。此外,Hcy与PP是脑梗死患者BaPWV升高的独立危险因素。结论高Hcy血症是引起动脉粥样硬化、脑梗死的主要原因,Hcy水平与动脉僵硬度密切相关。

Objective To analyze the correlation of Hcy and PWV in elderly patients with hypertensive cerebral infarction,and investigate the relationship between plasma Hcy levels and arterial stiffness.Methods The elderly patients with hypertensive cerebral infarction were divided into Hcy≥15 μmol/L group,and Hcy15 μmol/L group.At the same time,using 1 400 cm/s as the critical value,the normal group（BaPWV1 400 cm/s） and abnormal group（BaPWV≥1 400 cm/s） were divided.Determination of BMI,FPG,TG,LDLC,HDLC,TC,SBP,PP,PPI,BaPWV,and Hcyindex was establised.Results In Hcy≥15 μmol/L group,SBP,PP,PPI,BaPWV were significantly higher than those in Hcy15 μmol/L group（P〈0.05）.In WV abnormal group,SBP,PP,PPI,BaPWV were significantly higher than those in normal group（P〈0.05）.Hcy and SBP,PP,PPI,BaPWV showed positive correlation.BaPWV and SBP,PP,PPI,Hcy showed positive correlation.In addition,Hcy and PP were independent risk factors for BaPWV in patients with cerebral infarction.Conclusion The high Hcy hyperlipidemia is a major cause of atherosclerosis and cerebral infarction.The level of Hcy is closely related with arterial stiffness.